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British Microbiology Research Journal, ISSN: 2231-0886,Vol.: 9, Issue.: 6


Pathogenesis of the Influenza Virus in Diabetes Model Mice


Morihiro Ito1*, Hiromichi Kubota1, Tamaki Takeuchi1, Shanlou Qiao1, Masato Tsurudome2, Hideki Tsumura3, Akio Matsuda4, Machiko Nishio5 and Yasuhiko Ito1

1Department of Biomedical Sciences, College of Life and Health Science, Chubu University, Aichi, Japan.

2Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

3Division of Laboratory Animal Resources, National Research Institute for Child Health and Development, Tokyo, Japan.

4Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

5Department of Microbiology, Wakayama Medical University, Wakayama, Japan.

Article Information
(1) Gyanendra Singh, Gene Therapy & Louisiana Vaccine Center, School of Medicine, LSU Health Sciences Center, Louisiana, USA.
(1) Joel K Weltman, Brown University, USA.
(2) Gulsen Meral, Kagithane State Hospital, Istanbul, Turkey.
(3) Anonymous, University of Indonesia, Indonesia.
Complete Peer review History: http://sciencedomain.org/review-history/10286


When diabetes model mice and control mice were intranasally infected with the influenza virus (1 LD50), a significant higher mortality rate was observed in the diabetes model. The mortality rate became 100% at 10 days post infection. Furthermore, histopathological examination of lung tissue revealed a more enhanced inflammatory response in the diabetes model mice infected with the influenza virus. On the contrary, viral clearance from the lungs was suppressed in the diabetes model mice. The recruitment of macrophages was observed in the case of virus-infected control mice at 1 and 3 days post infection. Intriguingly, the number of macrophage in the lungs was not changed through the period of observation, thus the recruitment of macrophages in the lungs was not found in the virus-infected diabetes model mice.

Keywords :

Influenza virus; diabetes model mice; pathogenesis.

Full Article - PDF    Page 1-7

DOI : 10.9734/BMRJ/2015/18799

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