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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 10, Issue.: 11

Original-research-article

Neutrophil to Lymphocyte Ratio in Sickle Cell Anaemia Patients with Nephropathy

 

C. Aneke John1,2, O. Adegoke Adegbola3, C. Okocha Emmanuel1*, E. Onah Christian4, C. Ibeh Nancy5 and  A. Durosinmi Muheez2

1Departments of Haematology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

2Departments of Haematology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.

3Department of Chemical Pathology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.

4Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

5Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria.

Article Information

Editor(s):

(1) Ricardo Forastiero, Professor of Physiology and Internal Medicine, Haematology, Favaloro University, Argentina.

Reviewers:

(1) Anonymous, Fudan University, China.

(2) Anonymous, Erzincan University, Turkey.

(3) Adewoyin Ademola, University of Benin Teaching Hospital, Nigeria.

Complete Peer review History: http://sciencedomain.org/review-history/11328

Abstracts

Background: Sickle cell anaemia (SCA) is associated with a chronic inflammatory component; blood neutrophil to lymphocyte ratio (NLR) has been described as a marker of organ dysfunction and clinical outcome in diseases associated with systemic inflammation.

Objective: To evaluate NLR in Nigerian SCA patients with nephropathy.

Methods: Seventy-nine (79) SCA patients in steady state and 50 aged-matched controls were prospectively enrolled for this study. Full blood count and dip-stick macro-albuminuria were done for each participant and data was analyzed using descriptive and inferential statistics. The level of statistical significance was defined as p ≤ 0.05.

Results: The NLR was significantly higher in cases compared with controls (1.49±0.76 vs. 1.20±0.34, P=0.01) and the ANC was significantly higher in those with NLR ≥ 3.0 compared with those with NLR <3.0 (12.22±5.26x109/L vs. 6.10±2.96x109/L, respectively, P<0.001). Between cases with and without macro-albuminuria and controls, the means of NLR was significantly different (P=0.024). Macro-albuminuria was present in 16 (21.9%) of cases (all of which had NLR <3.0), this was not significantly correlated with NLR (r=-0.99, P=0.71).

Conclusion: No significant relationship was observed between NLR and SCA nephropathy.

Keywords :

Sickle cell anaemia; neutrophil/lymphocyte ratio; macro-albuminuria.

Full Article - PDF    Page 1-6

DOI : 10.9734/BJMMR/2015/20404

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