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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 10, Issue.: 11

Original-research-article

Serial DXA Bone and Soft Tissue Estimations in Growing Sheep

 

Christopher G. Schultz1, Jodie Dier2, Timothy R. Kuchel3, Robert J. Moore4 and Barry E. Chatterton1*

1Department of Nuclear Medicine, P.E.T and Bone Densitometry, Royal Adelaide Hospital, South Australia, Australia.

2Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia.

3Preclinical Imaging and Research Laboratories, S.A. Health and Medical Research Institute, Adelaide, South Australia, Australia.

4The Adelaide Centre for Spinal Research, S.A. Pathology, Adelaide, South Australia, Australia.

Article Information

Editor(s):

(1) Jingli Xu, College of Pharmacy, University of New Mexico, USA.

Reviewers:

(1) Claudiu Popescu, Carol Davila University of Medicine and Pharmacy, Romania.

(2) Maen Mahfouz, Arab American University Jenin, Palestine.

Complete Peer review History: http://sciencedomain.org/review-history/11325

Abstracts

Objectives: We aimed to establish the typical rate of skeletal mineralisation in the growing sheep. The sheep (size, ease of handling, cost and bone physiology) is establishing itself as an appropriate model for bone research. 

Materials and Methods: Body composition including bone density at 4 time points in the first two years was performed using DXA on a cohort of 14 developing lambs, as well as measurements in comparable adult sheep.

Results: Adult levels of bone density are reached by 18 months and lean body mass by 2 years in sheep.

Conclusions: Depending on the indications for studying bone and other metabolism in sheep, the rate of development should be considered in selecting the age group of experimental animals.

Keywords :

Bone densitometry; sheep; growth; normal range; dual energy X-ray absorptiometry.

Full Article - PDF    Page 1-9

DOI : 10.9734/BJMMR/2015/20544

Review History    Comments

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