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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 15, Issue.: 8


Tumor-infiltrating Lymphocytes are Independent Favorable Prognostic Indicator in 17-year Disease-Free Survival in Lymph Node-Negative Triple-Negative Breast Cancer Patient


Ana Lucia Amaral Eisenberg1*, Leila Chimelli1, Mirian Carvalho de Souza2, Fernanda Maria Braga Marinho3, Maria Theresa Accioly1, Marcelli Gatto de Brito1, Sérgio Koifman4# and Eliana Abdelhay5  

1Pathology Division (DIPAT), Nacional Cancer Institute (INCA), Rua Cordeiro da Graça, 156, Santo Cristo, Rio de Janeiro, RJ, CEP: 20220-400, Brazil.

2Epidemiology Division, Nacional Cancer Institute (INCA), Rua Marquês de Pombal, 125, 7th floor, Centro, Rio de Janeiro, RJ, CEP: 20230-240, Brazil.

3Mastology, Hospital do Câncer III, Nacional Cancer Institute (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, CEP: 20560-120, Brazil.

4Department of Epidemiology, National School of Public Health, Oswaldo Cruz Foundation (FIOCRUZ), Brazil.

5Stem Cell Laboratory, Bone Marrow Transplantation Unit, Nacional Cancer Institute (INCA), Praca Cruz Vermelha, 23, Centro, CEP: 20230-130, Rio de Janeiro, RJ, Brazil.

General Comment

1. Up to 6th August 2012, all SDI journals followed strict double-blind review policy to ensure neutral evaluation. During this review process identity of both, the authors and reviewers are kept hidden to ensure the unbiased evaluation. More information is available at this link.


2. We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (Detailed general information is available at this link). The identity of the authors and reviewers will be revealed to each other during this review process. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers (Example Link). If reviewers do not want to reveal their identities, we will honour that request. In that case, only the review reports will be published as ‘anonymous reviewer report’.


3. Additionally ‘Advanced OPEN peer review’ greatly helps in ‘continuity and advancement of science’. We firmly believe that all the files related to peer review of a manuscript are valuable and hold an important place in the continuity and advancement of science. If publishers publish the peer review reports along with published papers, this process can result in savings of thousands of hours of future authors during experiments, manuscript preparation, etc. by minimising the common errors after reading these previously published peer review reports. Therefore, as per our new official policy update, if the manuscript is published, all peer review reports will be available to the readers. All files (like the original manuscript, comments of the reviewers, revised manuscript, and editorial comment (if any)) related to the peer review, will be available in “Review history” link along with the published paper (Example Link).


4. Additionally, we believe that one of the main objectives of peer review system is ‘to improve the quality of a candidate manuscript’. Normally we try to publish the ‘average marks (out of 10)’ a manuscript received at initial peer review stage and at final publication stage to record its history of improvement during peer review. This process further increases the transparency. It is more important to record the ‘strength and weakness of a manuscript honestly’ than claiming that 'our peer review system is perfect’. Therefore, these transparent processes (i.e. publication of review history files and scores of a particular manuscript) additionally give a clear idea of the strength and weakness of a published paper to the readers. This process enhances the chances of proper use of the result of research (and or reduces the chances of misuse of the weakness of the findings of the paper). Thus this transparent process may prove to be highly beneficial for the society in the long run.


Specific Comment

Average Peer review marks at initial stage: 8.6/10

Average Peer review marks at publication stage: 9/10

Peer review history

Stage Description File 1 File 2
Stage 1 Original Manuscript File 1 NA
Stage 2 Peer review report_1(Viktoria – Varvara Palla, Greece) File 1 NA
Stage 2 Peer review report_2(Anonymous, Mexico) File 1 NA
Stage 2 Peer review report_3(Amrani Mariam, Morocco) File 1 NA
Stage 2 Peer review report_4(Ketan Vagholkar, India) File 1 NA
Stage 2 Revised MS v1 and Feedback v1 File 1 File 2
Stage 3 Comment_Editor_1_v1 File 1 NA

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