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European Journal of Medicinal Plants

European Journal of Medicinal Plants, ISSN: 2231-0894,Vol.: 12, Issue.: 4


Amelioratory Effect of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Function and Oxidative Stress Markers in Lead-intoxicated Rats


Christian Ejike Onah1*, Samuel Chukwuemeka Meludu2, Chudi Emmanuel Dioka3, Anaelechi Jude Onuegbu3, Chinwemma Florence Onah4, Daniel Lotanna Ajaghaku5, John Kennedy Nnodim6 and Obi Ejeatuluchukwu7

1Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

2Department of Human Biochemistry, Faculty of Basic Medical Sciences, NAU, Nnewi, Nigeria.

3Department of Chemical Pathology, Faculty of Medicine, NAU, Nnewi, Nigeria.

4Department of Nursing Services, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

5Department of Pharmacology/Toxicology, Faculty of Pharmaceutical Sciences, NAU, Awka, Nigeria.

6Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri, Imo State, Nigeria.

7Department of Pharmacology and Therapeutics, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi, Nigeria.


Article Information
(1) Thomas Efferth, Chair, Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry Johannes Gutenberg University, Germany.
(2) Marcello Iriti, Professor of Plant Biology and Pathology, Department of Agricultural and Environmental Sciences, Milan State University, Italy.
(1) Anthony Cemaluk C. Egbuonu, Michael Okpara University of Agriculture, Umudike, Nigeria.
(2) Pawan K. Singh, National Innovation Foundation, India.
Complete Peer review History: http://sciencedomain.org/review-history/13255




This study was designed to evaluate the effect of Moringa oleifera (MO) against lead acetate induced changes in some liver and kidney function parameters and oxidative stress markers in rats. Thirty six acclimatized Wistar rats were divided into six groups of six rats each (groups A-F). Different groups were exposed to 100 mg/kg lead acetate, different doses of MO, and combination of lead acetate and different doses of MO per oral (PO) for 6 weeks. Both their pre-treatment and post-treatment serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), gamma glutamyl transferase (GGT), bilirubin, albumin, total protein, urea, creatinine and uric acid as well as their post-treatment liver and kidney (homogenates) malondialdehyde (MDA), superoxide dismutase (SOD), glutathione-s-transferase (GST), and catalase (CAT) were estimated using standard methods. Lead acetate administration significantly increased the post-treatment levels of ALP, ALT, AST, GGT, bilirubin, urea, creatinine, and uric acid when compared with their pre-treatment and control levels (p<0.05). Lead acetate also significantly increased both liver and kidney MDA, but significantly decreased both liver and kidney SOD, GST and CAT (p<0.05). However, MO supplementation was associated with significant decreases in the levels of ALP, ALT, AST, GGT, bilirubin, urea, creatinine, uric acid, liver and kidney MDA and significant increases in the levels of both liver and kidney GST, SOD and CAT (p<0.05). This study showed lead induced changes in some liver and kidney function parameters as well as some oxidative markers of these organs and also revealed possible amelioratory effects to these changes after MO supplementation.


Keywords :

Antioxidant enzymes; kidney markers; lead; liver enzymes; Moringa oleifera.


Full Article - PDF    Page 1-12    Article Metrics


DOI : 10.9734/EJMP/2016/23763

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