+91 8617752708

British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 35 (11-20 December)


Differential and Combined Effects of Simvastatin and Vildagliptin on Angiogenic Markers and Oxidative Stress in Hind Limb Model of Ischemia in Diabetic Rats


Amany Shalaby1* and Heba Kamal2

1Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Egypt.
2Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Egypt.

Article Information


(1) Anonymous


(1) Anonymous

(2) Azza B. El-Remessy, University of Georgia, Georgia.

(3) Takeshi Ohta, Central Pharmaceutical Research Institute, Japan.

Complete Peer review History: http://www.sciencedomain.org/review-history/5698


Background: This study investigated the potential therapeutic effect of simvastatin and vildagliptin and their combination on angiogenesis in diabetic hind-limb ischemia.
Methods: 60 Sprague-dawely rats were divided into 5 groups, group A (normal control), group B (diabetic ischemic control), group C (simvastatin treated diabetic ischemic group), group D (vildagliptin treated diabetic ischemic group) and group E (combined sim. + vild. diabetic ischemic group). Parameters of angiogenesis as well as oxidative stress markers were evaluated.
Results: Increased capillary density in ischemic gastrocnemius tissue of diabetic rats treated with either simvastatin or vildagliptin with marked increase in its combination. This effect was accompanied by up-regulated plasma levels of HO-1, nitric oxide, vascular endothelial growth factor (VEGF) and expression of HIF-1 alpha levels. Tissue SOD and Catalase enzymes activities were normalized in groups treated with simvastatin or their combination with vildagliptin with concomitant decrease of lipid peroxidation.
Conclusion: Both vildagliptin and simvastatin has antioxidant and angiogenic effects and their combination could be a promising strategy in the management of diabetes associated peripheral arterial disease.

Keywords :

Simvastatin; vildagliptin; oxidative stress; diabetes; angiogenesis.

Full Article - PDF    Page 5587-5603

DOI : 10.9734/BJMMR/2014/10804

Review History    Comments

Our Contacts

Guest House Road, Street no - 1/6,
Hooghly, West Bengal,

+91 8617752708


Third Floor, 207 Regent Street
London, W1B 3HH,

+44 20-3031-1429