British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 35 (11-20 December)
Differential and Combined Effects of Simvastatin and Vildagliptin on Angiogenic Markers and Oxidative Stress in Hind Limb Model of Ischemia in Diabetic Rats
Amany Shalaby1* and Heba Kamal2 1Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Egypt.
2Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Egypt.
Amany Shalaby1* and Heba Kamal2
1Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Egypt.
(2) Azza B. El-Remessy, University of Georgia, Georgia.
(3) Takeshi Ohta, Central Pharmaceutical Research Institute, Japan.
Complete Peer review History: http://www.sciencedomain.org/review-history/5698
Background: This study investigated the potential therapeutic effect of simvastatin and vildagliptin and their combination on angiogenesis in diabetic hind-limb ischemia.
Methods: 60 Sprague-dawely rats were divided into 5 groups, group A (normal control), group B (diabetic ischemic control), group C (simvastatin treated diabetic ischemic group), group D (vildagliptin treated diabetic ischemic group) and group E (combined sim. + vild. diabetic ischemic group). Parameters of angiogenesis as well as oxidative stress markers were evaluated.
Results: Increased capillary density in ischemic gastrocnemius tissue of diabetic rats treated with either simvastatin or vildagliptin with marked increase in its combination. This effect was accompanied by up-regulated plasma levels of HO-1, nitric oxide, vascular endothelial growth factor (VEGF) and expression of HIF-1 alpha levels. Tissue SOD and Catalase enzymes activities were normalized in groups treated with simvastatin or their combination with vildagliptin with concomitant decrease of lipid peroxidation.
Conclusion: Both vildagliptin and simvastatin has antioxidant and angiogenic effects and their combination could be a promising strategy in the management of diabetes associated peripheral arterial disease.
Simvastatin; vildagliptin; oxidative stress; diabetes; angiogenesis.
Full Article - PDF Page 5587-5603
DOI : 10.9734/BJMMR/2014/10804Review History Comments