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British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 3, Issue.: 4 (October-December)

Original-research-article

Flavonol Glycosides from the Aerial Parts of Indigofera hirsuta and Anti-inflammatory Activity of n-butanol Fraction

 

L. S. Abbas1,2*, A. M. Musa2, M. I. Abdullahi3, M. G. Magaji4, M. I. Sule2 and B. Bawa5

1Department of Medical Laboratory, Hospital Services Management Board, Gusau, Nigeria.
2Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria.
3Department of Pharmaceutical and Medicinal Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria.
4Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria.
5National Agency for Food, Drugs Administration and Control (NAFDAC), Nigeria.

Article Information

Editor(s):

(1) Ali Nokhodchi, Medway School of Pharmacy, Universities of Kent and Greenwich, UK.

Reviewers:

(1) Anonymous.

(2) Anonymous.

(3) Geisson Marcos Nardi, University of Western of Santa Catarina, Brazil.

Complete Peer review History: http://www.sciencedomain.org/review-history/1869

Abstracts

Aims: The study aimed to phytochemically investigate the n-butanol soluble fraction of Indigofera hirsuta aerial parts and to evaluate the anti-inflammatory activity of the fraction using laboratory animal models.
Study Design: Isolation and elucidation of the bioactive compounds and anti-inflammatory activity investigation on n-butanol soluble fraction.
Place and Duration of Study: Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria - Nigeria. The study was completed between January-October, 2011.
Methodology: The compounds isolated were identified using different spectroscopic techniques. The n-butanol fraction was investigated for its effect on carrageenan-induced oedema in rat’s experimental model.
Results: Two Flavonol glycosides were isolated; Kaempferol-3-O-β-D-glucopyranoside (T2) and Kaempferol-7-O-β-D-glucopyranoside (Q3).The fraction significantly (P = .05) inhibited the carrageenan-induced paw oedema at doses of 150 and 300 mg/kg tested. The percentage anti-inflammatory effect of the highest dose tested (300 mg/kg) at the peak hour was higher than that of ketoprofen (10 mg/kg), the standard anti-inflammatory agent.
Conclusion: The result of this research suggests that the n-butanol soluble fraction of Indigofera hirsuta aerial parts contains bioactive compounds with anti-inflammatory activity.

Keywords :

Indigofera hirsuta; fabaceae; kaempferol glycosides; anti-inflammatory activity.

Full Article - PDF    Page 897-905 Article Metrics

DOI : 10.9734/BJPR/2013/3609

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