Annual Research & Review in Biology, ISSN: 2347-565X,Vol.: 9, Issue.: 2
Phylogenetic Considerations in the Evolutionary Development of Aminoglycoside Resistance Genes in Pathogenic Bacteria
Tommy Rodriguez1* 1Department of Research and Development, Pangaea Biosciences, Miami, FL, USA.
1Department of Research and Development, Pangaea Biosciences, Miami, FL, USA.
(1) George Perry, Dean and Professor of Biology, University of Texas at San Antonio, USA.
(1) Hazem Mohammed Ebraheem Shaheen, Damanhour University, Damanhour, Egypt.
(2) Anonymous, University of Sao Paulo, Brazil.
Complete Peer review History: http://sciencedomain.org/review-history/12792
This study revisits antibiotic resistance as a source of evolutionary development in pathogenic bacteria. By taking a molecular phylogenetic approach to this inquiry, I seek to find homologous correlations in antimicrobial resistance gene families across a broad spectrum of bacteria, as to identify the possible acquisition of those genes through divergent events in evolutionary context. In order to test this, I examine the various degrees of genetic similarity in two antimicrobial resistance genomic datasets, namely aadA1 & aadA2 aminoglycoside resistance genes, among bacteria that occur in a multitude of environments. Moreover, the results from phylogenetic analysis suggests that pathogenic antibiotic resistance for aadA1 & aadA2 aminoglycoside resistance genes may have been acquired through evolutionary events with a common ancestor of a soil-dwelling bacterium.
Bacteria; pathogens; phylogeny; molecular phylogenetics; aminoglycoside resistance genes; antimicrobial resistance; multiple sequence alignment; comparative genomics.
Full Article - PDF Page 1-8
DOI : 10.9734/ARRB/2016/22895Review History Comments