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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 8, Issue.: 11

Short Research Article

Effect of Combined Aerobic and Anaerobic Training on Hemodynamic Response, Serum Oxidative Stress Markers and Platelet ATP Synthase Activities in Patients with Coronary Heart Disease: A Pilot Study


José A. Villarruel-Sahagún1, Genaro G. Ortiz2*, Fermín P. Pacheco-Moisés3, Evelia Martínez-Cano2, Salvador G. Gómez4, Efraín Gaxiola-López4, Gustavo Marín-Pineda4, Pedro G. Fajardo4, Erika D. González-Renovato2, Sergio A. Sánchez-Luna2, Moisés A. Alatorre-Jiménez2, Fernando Cortés-Enríquez2 and Juan P. Sánchez-Luna2

1Axial. Medicina de Rehabilitación y Desarrollo Infantil CS. Guadalajara, Jalisco, México.
2Laboratorio de Mitocondria-Estrés Oxidativo & Enfermedad, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
3Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, Jalisco, México.
4Departamento de Readaptación Cardiovascular, Instituto Cardiovascular de Guadalajara (ICG), Hospital Bernardette, Guadalajara, Jalisco, México.

Article Information
(1) Gaetano Santulli, College of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA.
(2) Philippe E. Spiess, Department of Genitourinary Oncology, Moffitt Cancer Center, USA and Department of Urology and Department of Oncologic Sciences (Joint Appointment), College of Medicine, University of South Florida, Tampa, FL, USA.
(1) Anonymous, University of Bari, Italy.
(2) Anonymous, Grodno State Medical University, Belarus.
(3) Hiroyuki Tamemoto, Department Biochemistry, Jichi Medical University, Japan.
(5) Anonymous, Ain Shams University, Cairo, Egypt
Complete Peer review History: http://www.sciencedomain.org/review-history/9582


Background: The overall aim of this work was to study the impact of combined aerobic and anaerobic training in relation to hemodynamic response (heart rate, systolic blood pressure, and double product), serum oxidative stress markers (lipoperoxides, nitrites-nitrates) and platelet ATP synthase activities in patients with coronary heart disease.
Materials and Methods: Ten subjects, 9 male and 1 female, (mean age 57.7±7.2 years) with coronary heart disease participated in this study. Patients performed combined aerobic and anaerobic exercise for 24 sessions (three times a week).
Results: The results suggest myocardium adaptations, manifested in the reduction of heart rate with increased workloads and increased double product [(heart rate) x (systolic blood pressure)] according to the intensity, frequency and duration of training. The ATP synthesis rate was significantly increased at session 3 (post-exercise) compared to session 1 (pre exercise). Furthermore, rate of ATP hydrolysis was significantly decreased at session 24 (post-exercise 3) compared to session 1 (post-exercise 1). Serum lipid peroxidation products and nitric oxide catabolites were significantly diminished at session 24 (pre-exercise).
Conclusion: In some patients hemodynamic responses showed improvements in response to exercise. The exercise sessions induced lower levels of lipid peroxidation products, nitric oxide catabolites and ATPase activity. Conversely, ATP synthase activity showed higher values at the end of the experiment. These results confirm the beneficial effect of combined aerobic and anaerobic exercise.

Keywords :

Coronary heart disease; ATP synthase; oxidative stress; anaerobic exercise.

Full Article - PDF    Page 993-1002

DOI : 10.9734/BJMMR/2015/15421

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