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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 8, Issue.: 10


Therapeutic Implication of Terfezia claveryi Extract on Corneal Ulcer of Rabbit’s Eye


Yousef H. Aldebasi1, Manzoor A. Qureshi1,2*, Amjad A. Khan3, Salah M. Aly3,4 and Muhammad I. Ahmad1,5
1Department of Optometry, College of Applied Medical Sciences, Qassim University, Saudi Arabia.
2Department of Ophthalmology, Lliaquat University of Medical and Health Sciences, Pakistan.
3Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Saudi Arabia.
4Department of Pathology, College of Vet. Medicine, Suez Canal University, Ismailia, Eypt.
5Department of Ophthalmology, Punjab University, Allied Hospital, Punjab Medical College, Faisalabad, Pakistan.

Article Information
(1) Ian Dooley, Limerick Regional Hospital, Republic of Ireland.
(1) Wagner Loyola, Embrapa Swine and Poultry, Concordia, Brazil.
(2) Magda Ramadan Abdelwadood Abdeltwab, Ain Shamis University, Cairo Egypt.
(3) Mohammad Mostafa Khater, Ophthalmology Department, Tanta University Hospital, Egypt.
(4) Anonymous, Brazil.
Complete Peer review History: http://www.sciencedomain.org/review-history/9504


Aims: The aim of this study was to investigate the antimicrobial activity of Terfezia claveryi crude extract on induced corneal ulcer in rabbit’s eye.
Study Design: Study was carried out in Rabbits eye.
Place and Duration of the Study: This study was conducted in the experimental laboratories at College of Applied Medical Sciences of Qassim University during the period from March to June 2013.
Methodology: Crude aqueous extract of this truffle, in different concentrations, was introduced through intraperitoneal injection to rabbits for their safety dose.
Corneal epithelial wound was induced in different groups of rabbit’s eye with sodium hydroxide and later this wound was contaminated with some selected bacteria like Staphylococcus aureus and Escherchia coli to produce iatrogenic infection. The healing power of different concentrations of T. claveryi crude extract was observed by different clinical findings.
Results: We observed that 1.5% crude extract of this desert truffle significantly healed the corneal ulcer almost within 9 days. Delayed response in healing was observed with 3% T. claveryi, while 5% extract developed some extra corneal complications. The healing response of corneal ulcer to topical application of different concentrations of T. claveryi extract was compared with a synthetic antibiotic (Vigamox 0.5%) as a reference standard drug.
Conclusion: It was concluded that aqueous extract of T. claveryi has no significant toxic effects against liver and kidney function parameters. The antibacterial activity of this desert truffle recommends as an alternative medicine for some corneal infections. However, the therapeutic role of some specific ingredients present in this truffle needs further investigations.

Keywords :

Terfezia claveryi; antimicrobial activity; corneal ulcer; rabbits eye.

Full Article - PDF    Page 863-873

DOI : 10.9734/BJMMR/2015/17229

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