International Journal of Biochemistry Research & Review, ISSN: 2231-086X,Vol.: 7, Issue.: 4
Glycaemic Evaluation of Murraya koenigii in Alloxan-induced Diabetic Rabbits
T. Akande1, S. T. Balogun2, H. Abdullahi3, T. O. Ogundeko4* and M. S. Ramyil5 1Department of Chemical Pathology, College of Medicine and Health Sciences, Bingham University, Jos, Nigeria.
2Department of Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, Nigeria.
3Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, Ambrose Ali University, Ekpoma, Nigeria.
4Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Bingham University, Jos, Nigeria.
5Department of Medical Microbiology, College of Medicine and Health Sciences, Bingham University, Jos, Nigeria.
T. Akande1, S. T. Balogun2, H. Abdullahi3, T. O. Ogundeko4* and M. S. Ramyil5
1Department of Chemical Pathology, College of Medicine and Health Sciences, Bingham University, Jos, Nigeria.
(1) Chunying Li, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, USA.
(1) Musa Yakubu Tula, Department of Biological Science Technology, Federal Polytechnic, Mubi Adamawa State, Nigeria.
(2) Anonymous, Universidad Atonoma Del Estado De Morelos, Mexico.
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Background: Study was aimed to evaluate the antidiabetic activity of Murraya koenigii, a traditional medicinal plant (Curry leaf) in normoglycemic and alloxan-induced diabetes rabbits.
Methods: Antidiabetic activity of aqueous extract of M. koenigii in 100, 200 300 mg/k doses was determined by estimating blood glucose before and at 1, 2, 4, 8, 24, and 72 hours post treatment intervals in treated rabbits.
Results: Aqueous extract of Murraya koenigii showed a dose dependent antidiabetic activity with maximum effect established at 300 mg/kg. The extract also exhibited a significant (p<0.05) dose- dependent hypoglycemic effect on normal and alloxan-induced diabetic rabbits.
Conclusion: Murraya koenigii causes a reduction in blood glucose. This hypoglycemic property supports-its usein folkloric medicine as an antidiabetic agent and thus suggests a place for it in nutritional therapy in the management of diabetes mellitus and thus as an oral hypoglycaemic agent.
Murraya koenigii; hypoglycemic effect; alloxan-induced diabetes.
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