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Physical Review & Research International

Physical Review & Research International, ISSN: 2231-1815,Vol.: 3, Issue.: 1 (January-March)


Short Communication


Synthesis, X-ray Crystallographic Studies and Antibacterial Screening of 1-(5-(4-Chlorophenyl) thiazol-2-yl) hydrazine hydrobromide



Imtiaz Khan1*, Aliya Ibrar1, Muhammad Waqas1 and Jonathan M. White2

1Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan.
2Bio-21 Institute, School of Chemistry, University of Melbourne, Parkville-3052, Australia.




The synthesis of 1-(5-(4-chlorophenyl)thiazol-2-yl)hydrazine hydrobromide was achieved in a single step by condensation of 2-bromo-1-(4-chlorophenyl)ethanone with thiosemicarbazide in absolute ethanol. The structure of the target compound was deduced by modern spectroscopic techniques including FTIR, 1H and 13C NMR spectroscopy and unequivocally confirmed by crystallographic data. The title compound crystallized in the orthorhombic space group P 21 2 21 with unit cell parameters a = 6.6861(6) Å, b = 8.9683(12) Å, c = 20.4035(5) Å, α = β = γ = 90º, V = 1223.5(2) Å3, Z = 4, Dc = 1.751 mg/m3, F(000) = 640 and μ = 8.058 mm-1. The synthesized compound was also evaluated for antibacterial activity.


Keywords :

Condensation; thiazole; crystal structure; antibacterial activity.


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