Physical Review & Research International, ISSN: 2231-1815,Vol.: 3, Issue.: 1 (January-March)
Synthesis, X-ray Crystallographic Studies and Antibacterial Screening of 1-(5-(4-Chlorophenyl) thiazol-2-yl) hydrazine hydrobromide
Imtiaz Khan1*, Aliya Ibrar1, Muhammad Waqas1 and Jonathan M. White2 1Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan.
2Bio-21 Institute, School of Chemistry, University of Melbourne, Parkville-3052, Australia.
Imtiaz Khan1*, Aliya Ibrar1, Muhammad Waqas1 and Jonathan M. White2
1Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan.
(1) Aamer Saeed, Department of Chemistry, Quaid-1-Azam University, Islamabad-45320, Pakistan.
Complete Peer review History: http://www.sciencedomain.org/review-history/938
The synthesis of 1-(5-(4-chlorophenyl)thiazol-2-yl)hydrazine hydrobromide was achieved in a single step by condensation of 2-bromo-1-(4-chlorophenyl)ethanone with thiosemicarbazide in absolute ethanol. The structure of the target compound was deduced by modern spectroscopic techniques including FTIR, 1H and 13C NMR spectroscopy and unequivocally confirmed by crystallographic data. The title compound crystallized in the orthorhombic space group P 21 2 21 with unit cell parameters a = 6.6861(6) Å, b = 8.9683(12) Å, c = 20.4035(5) Å, α = β = γ = 90º, V = 1223.5(2) Å3, Z = 4, Dc = 1.751 mg/m3, F(000) = 640 and μ = 8.058 mm-1. The synthesized compound was also evaluated for antibacterial activity.
Condensation; thiazole; crystal structure; antibacterial activity.
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