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British Journal of Medicine and Medical Research

British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 8, Issue.: 7

 

Original Research Article

 

Vitamin D Receptor fok I Gene Polymorphism in Angiographically Proven Coronary Artery Disease Subjects: Case - Control Study

 

 

B. Sowjanya1*, Vettri Selvi2, B. Suneel1, D. Balakrishna1, D. R. Nagendra Kumar3, B. Phani Krishna4 and J. N. Naidu1
1Department of Biochemistry, Narayana Medical College, Nellore, Andhra Pradesh, India.
2Department of Human Genetics, Sri Ramachandra University, Chennai-TN, India.
3Department of Endocrinology, Sri Ramachandra University, Chennai-TN, India.
4Deapartment of Cardiology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India.

 

Abstracts

 

Aims: Coronary artery disease (CAD) is multifactorial disease resulting from modifiable and non modifiable risk factors. Gene polymorphism is one of the non modifiable risk factors, which may contribute to disease susceptibility. Identifying genetic polymorphisms is essential for better understanding of pathophysiology and treatment strategies for a particular disease. The objective of our study was to evaluate the association of vitamin D receptor (VDR) fok I polymorphism with CAD.
Place and Duration of the Study: The study samples were collected at Narayana Medical College Hospital, Nellore and genetic analysis done at Sri Ramachandra University, Chennai, India, from Nov 2013 to June 2014.
Materials and Methodology: The study included 40 angiographically proven CAD subjects as cases and 40 normal healthy controls .VDR fok I polymorphism was analysed by PCR-RFLP method. Chi Square and odds ratio was used to find the association.
Results: F allele frequency is 66.25% in CAD vs 52.5% in controls. There is no significant association of FF (p= 0.099), Ff (p= 0.851), ff (p= 0.138) with CAD.
Conclusion: There is no significant association of VDR fok I polymorphism with CAD in south Indian population. According to our study F allele frequency is more in CAD than in controls.

 

Keywords :

Coronary artery disease; vitamin D receptor; fok I; south Indian.

 

Full Article - PDF    Page 612-617    Article Metrics

 

DOI : 10.9734/BJMMR/2015/17845

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