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Cardiology and Angiology: An International Journal, ISSN: 2347-520X,Vol.: 3, Issue.: 3


Sex Hormones and Their Relationship with Leptin and Cardiovascular Risk Factors in Pre and Post-Menopausal Nigerian Women with Metabolic Syndrome


U. A. Fabian1, M. A. Charles-Davies1*, A. A. Fasanmade2, J. A. Olaniyi3, O. E. Oyewole4, M. O. Owolabi2, J. R. Adebusuyi5, O. Hassan5, B.M. Ajobo6, M. O. Ebesunun7, K. Adigun8, K. S. Akinlade1, O. G. Arinola1 and E. O Agbedana1
1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria.
2Department of Medicine, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria.
3Department of Haematology, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria.
4Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan 200284, Nigeria.
5Medical Social Services Department, University College Hospital, Ibadan 200212, Nigeria.
6Dietetics Department, University College Hospital, Ibadan 200212, Nigeria.
7Department of Chemical Pathology, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye 120005, Nigeria.
8General Out Patient Unit, University College Hospital, Ibadan 200212, Nigeria.

Article Information
(1) Francesco Pelliccia, Department of Heart and Great Vessels, University La Sapienza, Rome, Italy.
(1) A. Papazafiropoulou, Department of Internal Medicine and Diabetes Center, Tzaneio General Hospital of Piraeus, Greece.
(2) Mario Bernardo-Filho, Departamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Brazil.
(3) Ronald Wang, Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
(4) Pietro Scicchitano, Cardiology Department, San Giacomo Hospital, Monopoli, Italy.
Complete Peer review History: http://www.sciencedomain.org/review-history/8836


Metabolic Syndrome (MS), which affects 33.1% of Nigerians, predisposing them to cardiovascular disease (CVD) risk, has been associated with the female gender. The cardioprotective effect of oestradiol against CVD is now controversial and was investigated in premenopausal with MS (PRMMS) and postmenopausal women with MS (POMMS).
A total of 191 women (44 PRMMS, 126 POMMS and 21 premenopausal women without MS (PRM) (controls) with mean (s.d) age of 40.0 (6.9), 57.0 (8.8), 29.0 (6.8) years were participants of this study. Demography, blood pressure (BP), anthropometry, hormones, fasting plasma glucose (FPG) and lipids were obtained by standard methods. Data were significant at (P<.05).
Age, parity, all anthropometric measures, FPG, leptin, ET ratio and FSH were significantly higher while HDLC, testosterone and prolactin were significantly lower in PRMMS compared with controls (P<.03). In comparison of POMMS with PRMMS, age, parity, WHR, systolic BP, TG, FSH and LH were significantly higher while body weight, HC, and leptin were lower in POMMS compared with PRMMS (P<.05). DBP positively predicted oestradiol in PRM only (P=.044) while oestradiol positively predicted testosterone in PRMMS only (P<.001). In POMMS only, DBP positively predicted testosterone; testosterone, ET ratio and FSH positively predicted oestradiol while LDLC and oestradiol positively predicted the ET ratio (P<.03).
Metabolic syndrome may predispose both pre and postmenopausal women to the risk cardiovascular disease and type 2 diabetes mellitus. Oestradiol may protect against cardiovascular diseases in women without metabolic syndrome only.

Keywords :

Sex hormones; metabolic syndrome; cardiovascular disease; menopause; leptin.

Full Article - PDF    Page 149-156

DOI : 10.9734/CA/2015/15236

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