Quick Menu

Upcoming Journals

British Biotechnology Journal

British Biotechnology Journal, ISSN: 2231-2927,Vol.: 6, Issue.: 4


Original Research Article


Phytochemical Composition and Antimalarial Activity of Methanol Leaf Extract of Crateva adansonii in Plasmodium berghei Infected Mice



A. N. Tsado1*, L. Bashir2, S. S. Mohammed2, I. O. Famous2, A. M. Yahaya2, M. Shu’aibu2 and T. Caleb2

1Department of Basic and Applied Sciences, Niger State Polythechnic Zungeru, Nigeria.
2Department of Biochemistry, Federal University of Technology, P.M.B.65, Minna, Niger State, Nigeria.




The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanolic leaf extract of Crateva adansonii was investigated for its antimalarial activity against Plasmodium berghei (NK65) infected mice. A total of 15 mice were intraperitoneally infected with chloroquine sensitive P. berghei strain and divided into 5 equal groups, group 1 served as negative control (untreated), groups 2,3 and 4 were given 200, 400 and 600 mg/kg Crateva adansonii methanolic leaves extract respectively while group 5 served as positive control and was given 5 mg\kg chloroquine for five days. The phytochemical constituents of the plant extract were evaluated to elucidate the possibilities of their antimalarial effects. The extract produced a significant dose dependent decrease in the level of parasitaemia when compared to infected untreated group. Also, the extract at dose of 400 mg/kg and 600 mg/kg produced significant increase in body weight and PCV of the infected mice as compare to mice treated with 200 mg/kg of extract and infected untreated group. Phytochemical screening showed that the leaves extract contains alkaloids, anthraquinones, tannins, flavonoids, saponins cardiac glycosides and steroids. It is concluded that Crateva adansonii could serve as a possible source of antimalarial compounds.


Keywords :

Crateva adansonii; antimalarial; phytochemical; parasitarmia; Plasmodium berghei.


Full Article - PDF    Page 165-173    Article Metrics


DOI : 10.9734/BBJ/2015/16038

Review History    Comments

Search this site

Advanced Search

Announcement & News

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.