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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 7, Issue.: 6

Review Article

The Possible Mechanisms through Which Dietary Protein Increases Renal Blood Flow and Glomerular Filtration Rate


Esther O. Aluko1*, Victor U. Nna2 and Daniel A. Adekunbi3

1Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, AkwaIbom State, Nigeria.
2Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Cross River State, Nigeria.
3Department of Physiology, Benjamin S. Carson (Snr) School of Medicine, Babcock University, Ilishan-Remo, Nigeria.

Article Information
(1) Tibor Fulop, Division of Nephrology, University of Mississippi Medical Center, Jackson, USA.
(1) Ana D. O. Paixão, Physiology and Pharmacology, Federal University of Pernambuco, Brazil.
(2) Li Zuo, Department of Nephrology, Peking University First Hospital, Beijing, China.
(3) Ng Zhi Xiang, Department of Biomedical Science, Faculty of Medicine, MAHSA University, Malaysia.
Complete Peer review History: http://www.sciencedomain.org/review-history/8296


Obesity has been associated with a multitude of co-morbid conditions, most importantly with diabetes mellitus and cardiovascular diseases. Diet is one of the major key factors of a successful weight management schemes to ensure a healthy weight. High protein, low carbohydrate and low fat diets are reported to be effective for weight management and gained particular popularity in the recent past. As a result, most individuals have shifted to high protein diet in an attempt to lose weight or maintain a healthy weight or body composition. On the other hand, high dietary protein is well known to increase renal blood flow and glomerular filtration rate and may potentially increase the future risk of renal disease due to increased glomerular pressure and hyperfiltration injury. The mechanism by which protein diet acts on the kidney is not well known; however, multiple potential mechanisms have been postulated. This review discusses the possible mechanisms through which dietary protein intake may influence renal function parameters.

Keywords :

Glomerular filtration rate; hyperfiltration; kidney; nephron; protein; renal blood flow.

Full Article - PDF    Page 458-469

DOI : 10.9734/BJMMR/2015/16214

Review History    Comments

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