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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 7, Issue.: 5

Case Study

Bronchial Cytokine Changes Following Bronchial Resection and Reconstruction for Carcinoid Tumor


Nilgün KanlıoÄŸlu Kuman1*, Salih Çokpınar1, Aslıhan Karul2 and Fisun KaradaÄŸ3

1Faculty of Medicine, Department of Thoracic Surgery, Adnan Menderes University, Turkey.
2Faculty of Medicine, Department of Biochemistry, Adnan Menderes University, Turkey.
3Faculty of Medicine, Department of Pulmonology, Adnan Menderes University, Turkey.

Article Information
(1) E. Umit Bagriacik, Department of Immunology, Gazi University, Turkey.
(1) Suayib Yalcin, Department of Medical Oncology, Hacettepe University Institute of Cancer, Sihhiye, Ankara 06100, Turkey.
(2) D. Agrawal, Department of Cardiovascular and Thoracic Surgery, Institute of Medical Sciences, Banaras Hindu University, India.
Complete Peer review History:


As bronchial carcinoids are known to be notably rare, adequate histochemical investigations couldn’t have been carried out on these types of tumors hitherto. In this study, we investigated bronchial cytokines in a carcinoid tumor localized in the left main bronchus. Bronchial resection and reconstruction was performed without the lung resection. Bronchial lavage samples were obtained from both sides of main bronchial system preoperatively and postoperatively. TNF-α, IL-8 and IL6 levels were measured by ELÄ°SA. Preoperative TNF-α and IL-8 levels were found to be 2-folds and 5-folds higher on the tumor side respectively (TNF-α; 14.184 pg/ml and IL-8; 3359.86 pg/ml) compared to tumor-free bronchial system (TNF-α; 6.886 pg/ml, IL-8; 615.072 pg/ml). Interestingly, both cytokine levels were found to be equal and within normal ranges on both sides subsequent to bronchial resection and reconstruction. There were no significant difference in IL-6 levels between two bronchial systems preoperatively (IL-6 levels of right bronchus, 16.44 pg/ml; levels of left bronchus, 19.11 pg/ml). However, there was more than four-fold increase in postoperative levels (IL-6 level; 89.41 pg/ml).
In our study, we found that preoperative TNF-α and IL-8 levels were higher compared to the postoperative ones; whereas IL-6 levels showed a significant increase, postoperatively. These findings led us through the idea that carcinoid tumors might be activating the inflammatory process among TNF-α and IL-8 and the surgical bronchoplastic procedure could be the cause of enhanced IL-6 response.

Keywords :

Bronchial resection; reconstruction; carcinoid tumor; cytokines.

Full Article - PDF    Page 432-437 Article Metrics

DOI : 10.9734/BJMMR/2015/16006

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