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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 6, Issue.: 11

Original-research-article

Relationship of Oral Lesions and CD4 Count in Female HIV Patients in South Western Nigeria

 

O. M. Eweka1*, M. Okoh2, G. A. Agbelusi1, B. D. Saheeb3, O. Odukoya4 and F. O. Omoregie2

1Department of Preventive Dentistry, College of Medicine University of Lagos, Lagos, Nigeria.
2Department of Oral Pathology and Medicine, University of Benin Teaching Hospital, Benin, Edo State, Nigeria.
3Department of Oral and Maxillofacial Surgery, University of Benin Teaching Hospital, Benin, Edo State, Nigeria.
4Department of Oral Biology / Pathology, College of Medicine University of Lagos, Lagos, Nigeria.

Article Information
Editor(s):
(1) Roberto Manfredi, Department of Medical and Surgical Sciences, University of Bologna, Italy.
Reviewers:
(1) Mathew Folaranmi Olaniyan, Department of Medical Laboratory Science, Achievers University, Nigeria.
(2) Anonymous, Brazil.
(3) Vicente Estrada, Hospital Clinico San Carlos, Complutense University, Spain.
Complete Peer review History: http://www.sciencedomain.org/review-history/7842

Abstracts

Background: Oral lesions have been reported to be early clinical features of HIV infection.
Objective: The purpose of this study was to establish the prevalence of oral lesions in HIV Seropositive female patients and correlate the CD4 count with the appearance of oral lesions in the female patients attending Lagos University Teaching Hospital (LUTH) and University of Benin Teaching Hospital, Benin (UBTH).
Methods: A prospective study was undertaken in 172 newly diagnosed adult HIV infected female patients (not on antiretroviral therapy), who attended the PEPFAR clinic at LUTH and the HIV Clinic of the University of Benin Teaching Hospital, Benin City, Nigeria. They were assessed for oral lesions which were evaluated using EEC/WHO (2003) – Classification on the diagnostic criteria for oral lesions in HIV. Data were collected using an interviewer administered questionnaire. Following Oral examination undertaken, oral lesions were detected, recorded and treated. CD4+ values were evaluated from blood samples of patient at presentation.
Results: A total of 172 HIV infected female patients were enrolled into the study. The age range of the participants was 18-65 years, (mean age: 36 + 9.2 years). The commonest oral lesion observed was pseudomembranous candidiasis (n=42, 35.9%); followed by melanotic hyperpigmentation (n=14, 12%) and Linear gingival erythema (LGE) was 12 (10.3%) cases. A high prevalence of oral lesions was seen in patients with low CD4+ count (<200 cells/mm3). P value = .001.
Conclusion: Oral lesions are common features of HIV and were seen more in patients with low CD4 count.

Keywords :

HIV; female; oral lesions; CD4 count.

Full Article - PDF    Page 1063-1068

DOI : 10.9734/BJMMR/2015/12618

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