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International Journal of Biochemistry Research & Review, ISSN: 2231-086X,Vol.: 6, Issue.: 2

Original-research-article

Protective Effect of Costus afer on Lipid Profile and Hepatic Damage in Ethanol - Induced Liver Cirrhosis in Rats

 

Ayakeme Tonkiri1*, E. B. Essien1, J. O. Akaninwor1 and Ronami S. Ogbomade1

1Department of Biochemistry, Faculty of Chemical Science, College of Natural and Applied Medical Sciences. University of Port-Harcourt, Nigeria.

Article Information
Editor(s):
(1) Chunying Li, Department of Biochemistry and Molecular Biology Wayne State University School of Medicine, Detroit, USA.
Reviewers:
(1) Anonymous, Nigeria.
(2) Ndomou Mathieu, Department of Biochemistry, Faculty of Science, University of Douala, Cameroon.
(3) Anonymous, Iran.
(4) Anonymous, Pakistan.
Complete Peer review History: http://www.sciencedomain.org/review-history/7624

Abstracts

Aim: The study is to investigate the impact of Costus afer methanolic stem extract on lipid metabolic profiles and bilirubin levels in alcohol-induced liver cirrhosis progression in rats.
Materials and Methods: Male wistar strain albino rats were randomly divided into five groups: Control (normal feed and water only), Costus afer control (CA), Ethanol control (Ethanol), ethanol + Costus afer (60mg) treated rats (CA + ETHANOL) and ethanol + Costus afer (120mg) treated rats (CACA + ETHANOL). Serum levels of lipids and bilirubin were measured.
Results: The result showed that ethanol only administration caused triglyceride, cholesterol, low density lipoprotein and bilirubin to increase by 46.1%, 64.3%, 10.71% and 0.18% respectively compared to control rats (p<0.05). High density lipoprotein was shown to have decreased by 11.2% compared to the control.
Conclusion: Evidence suggests that oxidative stress is involved in the pathophysiology of complications and alcoholic diseases. Co-treatment with the extract modestly modulates the effect of ethanol to near normal.

Keywords :

Costus afer; triglyceride; cholesterol; low density lipoprotein; high density lipoproteins; bilirubin.

Full Article - PDF    Page 53-61

DOI : 10.9734/IJBCRR/2015/14577

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