International Journal of Biochemistry Research & Review, ISSN: 2231-086X,Vol.: 6, Issue.: 2
Protective Effect of Costus afer on Lipid Profile and Hepatic Damage in Ethanol - Induced Liver Cirrhosis in Rats
Ayakeme Tonkiri1*, E. B. Essien1, J. O. Akaninwor1 and Ronami S. Ogbomade1 1Department of Biochemistry, Faculty of Chemical Science, College of Natural and Applied Medical Sciences. University of Port-Harcourt, Nigeria.
Ayakeme Tonkiri1*, E. B. Essien1, J. O. Akaninwor1 and Ronami S. Ogbomade1
1Department of Biochemistry, Faculty of Chemical Science, College of Natural and Applied Medical Sciences. University of Port-Harcourt, Nigeria.
(1) Chunying Li, Department of Biochemistry and Molecular Biology Wayne State University School of Medicine, Detroit, USA.
(1) Anonymous, Nigeria.
(2) Ndomou Mathieu, Department of Biochemistry, Faculty of Science, University of Douala, Cameroon.
(3) Anonymous, Iran.
(4) Anonymous, Pakistan.
Complete Peer review History: http://www.sciencedomain.org/review-history/7624
Aim: The study is to investigate the impact of Costus afer methanolic stem extract on lipid metabolic profiles and bilirubin levels in alcohol-induced liver cirrhosis progression in rats.
Materials and Methods: Male wistar strain albino rats were randomly divided into five groups: Control (normal feed and water only), Costus afer control (CA), Ethanol control (Ethanol), ethanol + Costus afer (60mg) treated rats (CA + ETHANOL) and ethanol + Costus afer (120mg) treated rats (CACA + ETHANOL). Serum levels of lipids and bilirubin were measured.
Results: The result showed that ethanol only administration caused triglyceride, cholesterol, low density lipoprotein and bilirubin to increase by 46.1%, 64.3%, 10.71% and 0.18% respectively compared to control rats (p<0.05). High density lipoprotein was shown to have decreased by 11.2% compared to the control.
Conclusion: Evidence suggests that oxidative stress is involved in the pathophysiology of complications and alcoholic diseases. Co-treatment with the extract modestly modulates the effect of ethanol to near normal.
Costus afer; triglyceride; cholesterol; low density lipoprotein; high density lipoproteins; bilirubin.
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