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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 6, Issue.: 4

Original-research-article

The Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cells

 

Faiza A. Mahboub1*, Faten A. Khorshid2 and Abdul-Hamid M. Emwas3

1Biology Department, Faculty of Applied Science, Umm Al-Qura University, Makah Al-Mukaramah, Saudi Arabia.
2Department of Biology, Faculty of Science, King Abdulaziz University (KAU), Saudi Arabia.
3Imaging and Characterization Core laboratory, King Abdullah University for Science and Technology (KAUST), Saudi Arabia.

Article Information
Editor(s):
(1) Franciszek Burdan, Experimental Teratology Unit, Human Anatomy Department, Medical University of Lublin, Poland And Radiology Department, St. John’s Cancer Center, Poland.
Reviewers:
(1) Manuel Salmeron-Sanchez, Division of Biomedical Engineering, School of Engineering, University of Glasgow, UK.
(2) Renyou Gan, School of biological sciences, The University of Hong Kong, Hong Kong.
(3) Anonymous, Italy.
(4) Anonymous, Malaysia.
(5) Anonymous, Egypt.
Complete Peer review History: http://www.sciencedomain.org/review-history/7351

Abstracts

Aim of the work: Animal urine, including that of camels, has long been used for the therapeutic management of human ailments. In this study, we sought to characterize the cytotoxic properties of newly derived purified fractions from previously described camel urine extract (PMF) on various cancer cell lines.
Methodology: Two new size dissimilar fractions of PMF (large and small) were obtained by fractionalizing PMF using 3kD and 50kD membrane filters. A SRB cytotoxicity assay of the PMF fractions was performed on cancer cell lines (A549, HCT116, HepG2, MCF-7, U251 and Hela) as well as normal cell lines (human fibroblast cell line and Vero).
Results: This study showed that the newly derived and more purified fraction of PMF (new PMF) possesses effective and selective anti-cancer properties against several types of cancer cell lines.
Conclusion: This study, as well as previous ones, suggests that camel urine extracts (old and new PMF) may provide newer therapeutic alternatives to clinically manage cancer patients. However, further studies are needed to verify these positive preliminary results.

Keywords :

Camel; urine; cancer; PMF; A549; HCT116; HepG2; MCF-7; U251; Hela and NMR spectroscopy.

Full Article - PDF    Page 384-396

DOI : 10.9734/BJMMR/2015/12271

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