British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 6, Issue.: 3
Can Selenite be an Ultimate Inhibitor of Ebola and Other Viral Infections?
Boguslaw Lipinski1* 1Joslin Diabets Center, Harvard Medical School, Boston MA 02215, USA.
1Joslin Diabets Center, Harvard Medical School, Boston MA 02215, USA.
(1) Francesco Angelico, Professor, Department of Public Health and Infectious Diseases, Sapienza University Medical School, Rome, Italy.
(1) Fernanda Carlini Cunha dos Santos, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
(2) Adeolu Oladayo Akinboro, Dermatology and Venereology Unit, Department of Internal Medicine, Ladoke Akintola University of Technology, and LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
Complete Peer review History: http://www.sciencedomain.org/review-history/7276
It is known that the virulence of Ebola and other RNA enveloped viruses involves in the first step their attachment to host cell membranes. Following this initial step the virus enters the target cell cytoplasm by forming hydrophobic spikes that make holes in the membrane lipid bilayer. Formation of such spikes is catalyzed by the reduced form of viral protein disulfide isomerase (PDIred) thus initiating chain of disulfide exchange reactions. Consequently, hydrophobic protein epitopes become exposed, which in the absence of proper chaperones form hydrophobic ‘spikes’ capable of penetrating the host cell membranes. In this communication evidence is discussed showing that the chain of disulfide exchange events can be inhibited by a small redox molecule – sodium selenite. It is suggested that this inexpensive and readily available food supplement can be an ultimate inhibitor of Ebola and other enveloped viral infections.
Ebola virus; hydrophobicity; protein disulfide exchange; sodium selenite.
Full Article - PDF Page 319-324
DOI : 10.9734/BJMMR/2015/14858Review History Comments