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British Journal of Medicine and Medical Research

British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 6, Issue.: 3

 

Opinion Article

 

Can Selenite be an Ultimate Inhibitor of Ebola and Other Viral Infections?

 

 

Boguslaw Lipinski1*

1Joslin Diabets Center, Harvard Medical School, Boston MA 02215, USA.

 

Abstracts

 

It is known that the virulence of Ebola and other RNA enveloped viruses involves in the first step their attachment to host cell membranes. Following this initial step the virus enters the target cell cytoplasm by forming hydrophobic spikes that make holes in the membrane lipid bilayer. Formation of such spikes is catalyzed by the reduced form of viral protein disulfide isomerase (PDIred) thus initiating chain of disulfide exchange reactions. Consequently, hydrophobic protein epitopes become exposed, which in the absence of proper chaperones form hydrophobic ‘spikes’ capable of penetrating the host cell membranes. In this communication evidence is discussed showing that the chain of disulfide exchange events can be inhibited by a small redox molecule – sodium selenite. It is suggested that this inexpensive and readily available food supplement can be an ultimate inhibitor of Ebola and other enveloped viral infections.

 

Keywords :

Ebola virus; hydrophobicity; protein disulfide exchange; sodium selenite.

 

Full Article - PDF    Page 319-324    Article Metrics

 

DOI : 10.9734/BJMMR/2015/14858

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