European Journal of Food Research & Review, ISSN: 2231-0878,Vol.: 2, Issue.: 4 (October-December)
Scientific Opinion on the Regulatory Status of 1,3-Dimethylamylamine (DMAA)
Bastiaan J. Venhuis1* and Dries de Kaste1 1RIVM - National Institute for Public Health and the Environment, P.O. Box 1, NL-3720 BA Bilthoven, The Netherlands.
Bastiaan J. Venhuis1* and Dries de Kaste1
1RIVM - National Institute for Public Health and the Environment, P.O. Box 1, NL-3720 BA Bilthoven, The Netherlands.
1,3-Dimethylamylamine (DMAA) is a pressor amine often found in food supplements for athletes at dosages of 25-65 mg. Historically, the compound has been used as a nasal decongestant but its oral application is largely unstudied leaving the regulatory status of such food supplements as unlicensed medicines undetermined. We therefore reviewed the literature on DMAA and similar amines in order to deduce an effective oral dosage. Based on our findings we conclude that oral preparations with >4 mg DMAA per dose unit should be considered as effective as a bronchodilator. Food supplements that exceed that limit are in fact subject to the Medicines Act and require licensing. Dosages higher than 100-200 mg are expected to cause serious adverse events.
1,3-Dimethylamylamine (DMAA); geranamine; regulatory status; food supplements; oral efficacy.Review History Comments
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