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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 5, Issue.: 10

Original-research-article

Prevalence of Down Syndrome in Western India: A Cytogenetic Study

 

Gadhia Pankaj1*, Kathiriya Avani1 and Vaniawala Salil1

1Molecular Cytogenetic Unit, S.N.Gene Laboratory and Research Centre President Plaza – A, Surat, India.

Article Information
Editor(s):
(1) Paulo Ricardo Gazzola Zen, Departament of Clinical Medicine, Federal University of Health Sciences of Porto Alegre (UFCSPA), Brazil.
Reviewers:
(1) Qinghua zhou, Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
(2) Anonymous, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.
(3) Anonymous, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
(4) Anonymous, Mansoura University, Egypt.
Complete Peer review History: http://www.sciencedomain.org/review-history/6789

Abstracts

Aim: To study the prevalence of Down syndrome by conventional chromosome analysis and G-banded karyotyping.
Materials and Methods: A retrospective analysis was performed on the case records of2750 paediatrics patients, of which 682 cases of confirmed Down syndrome was recorded by G-banding karyotyping.
Results: Non-disjunction was the most common type of abnormality followed by Robertsonian translocation and lastly mosaic in ratio of 92.2:7.0:0.73 respectively.
Conclusion: Results suggest that advanced maternal age is classic risk factor attributed to the incidences of Down syndrome.

Keywords :

Down syndrome; prevalence; Western India; G-banded karyotype; mosaic.

Full Article - PDF    Page 1255-1259

DOI : 10.9734/BJMMR/2015/13648

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