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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 29 (11-20 October)

Original-research-article

Use of Homeostatic Model Assessment Indexes for the Identification of Metabolic Syndrome and Insulin Resistance among Cuban-Americans: A Cross Sectional Study

 

Joel C. Exebio1, Sahar Ajabshir1, Gustavo G. Zarini1, Joan Vaccaro1 and Fatma G. Huffman1*

1Florida International University, Robert Stempel School of Public Health and Social Work, Department of Dietetics and Nutrition, AHC I - 435, 11200 S. W. 8th Street, Miami, FL 33199, USA.

Article Information

Editor(s):

(1) E. Umit Bagriacik, Immunology Research Center, Gazi University, Faculty of Medicine, Department of Immunology, Turkey.

Reviewers:

(1) Anonymous.

(2) Amal Ahmed Mohamed Mohamed, National Hepatology and Tropical Medicine Research Institute, Egypt.

Complete Peer review History: http://www.sciencedomain.org/review-history/5131

Abstracts

Aim: to determine cut off points for The Homeostatic Model Assessment Index 1 and 2 (HOMA-1 and HOMA-2) for identifying insulin resistance and metabolic syndrome among a Cuban-American population.
Study Design: Cross sectional.
Place and Duration of Study: Florida International University, Robert Stempel School of Public Health and Social Work, Department of Dietetics and Nutrition, Miami, FL from July 2010 to December 2011.
Methodology: Subjects without diabetes residing in South Florida were enrolled (N=146, aged 37 to 83 years). The HOMA1-IR and HOMA2-IR 90th percentile in the healthy group (n=75) was used as the cut-off point for insulin resistance. A ROC curve was constructed to determine the cut-off point for metabolic syndrome.
Results: HOMA1-IR was associated with BMI, central obesity, and triglycerides (P<0.05). HOMA2-IR was associated with BMI, central obesity, total cholesterol, HDL-cholesterol and LDL-cholesterol (P<0.05). The cut-off points for insulin resistance for HOMA-1 and HOMA-2 were >3.95 and >2.20 and for metabolic syndrome were >2.98 (63.4% sensitivity and 73.3% specificity) and >1.55 (60.6% sensitivity and 66.7% specificity), respectively.
Conclusion: HOMA cut-off points may be used as a screening tool to identify insulin resistance and metabolic syndrome among Cuban-Americans living in South Florida.

Keywords :

Insulin resistance; metabolic syndrome; homeostatic model assessment; Cuban Americans.

Full Article - PDF    Page 4824-4833

DOI : 10.9734/BJMMR/2014/8988

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