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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 28 (01-10 October)

Original-research-article

Dyslipidaemia in Hypertensives in South-South Nigeria

 

J. O. Idemudia1*

1Department of Chemical Pathology, College of Medicine, University of Benin, Benin City, Edo State, Nigeria.

Article Information

Editor(s):

(1) Salomone Di Saverio, Emergency Surgery Unit, Department of General and Transplant Surgery, S. Orsola Malpighi University Hospital, Bologna, Italy.

Reviewers:

(1) Makusidi Aliyu Muhammad, Usmanu Danfodiyo University, Nigeria.

(2) Sanda Mihaela Popescu, University of Medicine and Pharmacy of Craiova, Romania.

Complete Peer review History: http://www.sciencedomain.org/review-history/5051

Abstracts

Background: There is a strong relationship between hypertension and dyslipidaemia, and both can increase the risk of developing coronary heart disease.
Methods: A total of One hundred and eighty (180) participants were recruited for this study; out of which, there was one hundred and fifty (150) hypertensive patients and thirty (30) control subjects that were age- and socio-economically matched with the hypertensive patients. Lipid profile test was carried out for them using standard laboratory techniques.
Results: Fifty-four percent (n=69) of the hypertensive patients were females; majority of the female hypertensive patients were within the age bracket of 50-59years (45.7%) while majority of the male hypertensive patients were within the age bracket of 40-49 years (53.6%). With the exception of HDL-cholesterol values which were comparable with the Normotensive controls, the hypertensive patients had significantly higher lipid profiles (triglyceride, total cholesterol and LDL-cholesterol). There was positive correlation between total cholesterol, triglycerides (0.399, p<0.05), LDL-cholesterol (r=0.609, p<0.05) and HDL-cholesterol (r=0.866, p<0.05) among the hypertensive patients, also, HDL-cholesterol positively correlated with LDL-cholesterol (r=0.218, p<0.05) but in the normotensive patients, LDL-cholesterol negatively correlated with triglyceride (r=-0.409, p<0.05) and positively correlated with total cholesterol (r=0.876, p<0.05).
Conclusion: Hypertensive Nigerians have significantly higher lipid profile except the HDL-cholesterol which is comparable in both hypertensive and Normotensive Nigerians. This shows that the dyslipidaemia in hypertensive Nigerians majorly involve plasma total cholesterol, triglyceride and LDL-cholesterol.

Keywords :

Dyslipidaemia; hypertension; normotensives; coronary heart disease; Nigerians.

Full Article - PDF    Page 4742-4750

DOI : 10.9734/BJMMR/2014/10678

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