British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 28 (01-10 October)
Dyslipidaemia in Hypertensives in South-South Nigeria
J. O. Idemudia1* 1Department of Chemical Pathology, College of Medicine, University of Benin, Benin City, Edo State, Nigeria.
J. O. Idemudia1*
1Department of Chemical Pathology, College of Medicine, University of Benin, Benin City, Edo State, Nigeria.
(1) Salomone Di Saverio, Emergency Surgery Unit, Department of General and Transplant Surgery, S. Orsola Malpighi University Hospital, Bologna, Italy.
(1) Makusidi Aliyu Muhammad, Usmanu Danfodiyo University, Nigeria.
(2) Sanda Mihaela Popescu, University of Medicine and Pharmacy of Craiova, Romania.
Complete Peer review History: http://www.sciencedomain.org/review-history/5051
Background: There is a strong relationship between hypertension and dyslipidaemia, and both can increase the risk of developing coronary heart disease.
Methods: A total of One hundred and eighty (180) participants were recruited for this study; out of which, there was one hundred and fifty (150) hypertensive patients and thirty (30) control subjects that were age- and socio-economically matched with the hypertensive patients. Lipid profile test was carried out for them using standard laboratory techniques.
Results: Fifty-four percent (n=69) of the hypertensive patients were females; majority of the female hypertensive patients were within the age bracket of 50-59years (45.7%) while majority of the male hypertensive patients were within the age bracket of 40-49 years (53.6%). With the exception of HDL-cholesterol values which were comparable with the Normotensive controls, the hypertensive patients had significantly higher lipid profiles (triglyceride, total cholesterol and LDL-cholesterol). There was positive correlation between total cholesterol, triglycerides (0.399, p<0.05), LDL-cholesterol (r=0.609, p<0.05) and HDL-cholesterol (r=0.866, p<0.05) among the hypertensive patients, also, HDL-cholesterol positively correlated with LDL-cholesterol (r=0.218, p<0.05) but in the normotensive patients, LDL-cholesterol negatively correlated with triglyceride (r=-0.409, p<0.05) and positively correlated with total cholesterol (r=0.876, p<0.05).
Conclusion: Hypertensive Nigerians have significantly higher lipid profile except the HDL-cholesterol which is comparable in both hypertensive and Normotensive Nigerians. This shows that the dyslipidaemia in hypertensive Nigerians majorly involve plasma total cholesterol, triglyceride and LDL-cholesterol.
Dyslipidaemia; hypertension; normotensives; coronary heart disease; Nigerians.
Full Article - PDF Page 4742-4750
DOI : 10.9734/BJMMR/2014/10678Review History Comments