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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 28 (01-10 October)

Original-research-article

Antidiabetic Activity of Hydroalcoholic Extracts of Nardostachys jatamansi in Alloxan-induced Diabetic Rats

 

M. A. Aleem1*, B. Syed Asad1, Tasneem Mohammed2, Riyaz Ahmed Khan1, M. Farooq Ahmed1, A. Anjum3 and M. Ibrahim1,3,4

1Department of Medicinal Chemistry and Pharmacology, Nizam Institute of Pharmacy and Research Center, Deshmukhi (V), Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), India-508284, India.
2Department of Gastroenterology and Hepatology, Ibn Sina National College of Medical Sciences, Al Mahjar, Jeddah-21418, K. S. A, Saudi Arabia.
3Department of chemistry, Asian Institute of Advance Scientific and Pharmaceutical Research, Hyderabad, Andhra Pradesh, India.
4Center for Liver Research and Diagnostics, Deccan College of Medical Sciences and Allied Hospitals Kanchanbagh, Hyderabad 500 058, Andhra Pradesh, India.

Article Information

Editor(s):

(1) Sinan Ince, University of Afyon Kocatepe, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, ANS Campus, 03030 Afyonkarahisar/Turkey.

Reviewers:

(1) Anonymous.

(2) Anonymous.

Complete Peer review History: http://www.sciencedomain.org/review-history/5024

Abstracts

A review of literature indicates that diabetes mellitus was fairly well known and well conceived as an entity in India with complications like angiopathy, retinopathy, nephropathy, and causing neurological disorders. The antidiabetic study was carried out to estimate the anti hyperglycemic potential of Nardostachys Jatamansi rhizome’s hydro alcoholic extracts in alloxan induced diabetic rats over a period of two weeks. The hydroalcoholic extract HAE1 at a dose (500mg/kg) exhibited significant antihyperglycemic activity than extract HAE2 at a dose (500mg/kg) in diabetic rats. The hydroalcoholic extracts showed improvement in different parameters associated with diabetes, like body weight, lipid profile and biochemical parameters. Extracts also showed improvement in regeneration of β-cells of pancreas in diabetic rats. Histopathological studies strengthen the healing of pancreas by hydro alcoholic extracts (HAE1& HAE2) of Nardostachys Jatamansi, as a probable mechanism of their ant diabetic activity.

Keywords :

Nardostachys jatamansi; diabetes mellitus; alloxan; hypoglycemic effect; hydroalcoholic extract.

Full Article - PDF    Page 4665-4673

DOI : 10.9734/BJMMR/2014/11282

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