British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 15 (21-31 May)
An Appraisal of Screening Methods for Gestational Diabetes Mellitus
M. Najimudeen1* and K. Sachchithanantham1 1Melaka Manipal Medical College, Malaysia.
M. Najimudeen1* and K. Sachchithanantham1
1Melaka Manipal Medical College, Malaysia.
(1) Kate S Collison, Department of Cell Biology, King Faisal Specialist Hospital & Research Centre, Saudi Arabia.
(2) Mohamed Essa, Department of Food Science and Nutrition, Sultan Qaboos University, Oman.
(3) Kyuzi Kamoi, Niigata Prefecture University, Japan.
(4) Sinan Ince, Department of Pharmacology and Toxicology, University of Afyon Kocatepe, Turkey.
(2) Godson Ugwoke Eze, Delta State University Teaching Hospital, Nigeria.
Complete Peer review History: http://www.sciencedomain.org/review-history/3894
The importance of screening and diagnosis of gestational diabetes mellitus (GDM) is universally accepted but there is controversy and uncertainty about the most suitable method of screening among various populations.
The majority of the patients are asymptomatic. After nearly 60 years of research the screening and diagnosis of GDM, universal screening evades uniform acceptance and remains debatable. Multiple studies, numerous global consensus conferences and several multicenter trials had not identified the unique procedure. Surprisingly still there is uncertainty regarding the most effective method of screening among various populations.
The prevalence of GDM varies from less than 1% to more than 10%
It is increasing due to dietary habits, overweight, maternal age, ethnicity, family history and past history .Prevalence vary due to the use of a wide range of definitions and diagnostic test criteria, as well as variations across regions and ethnic groups.
The merits of available screening methods such as urine testing for glycosuria, 50g glucose challenge test (GCT), random blood sugar testing, fasting blood glucose (FBS) , estimation of glycosylated haemoglobin , fructosamine ,75g oral Glucose Tolerance Test (75g OGTT) and two step approach (Combination of methods) are analysed.
In countries where funds are limited, certainly the selective screening is cost effective compared to whole population screening.
After many decades of research, only up-to-date considerations are Random blood glucose, O’Sullivan, 75g and Complete OGTT.
Gestational diabetes mellitus; screening methods; universal screening; selective screening; combination methods.
Full Article - PDF Page 2853-2865
DOI : 10.9734/BJMMR/2014/6166Review History Comments