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International Research Journal of Pure and Applied Chemistry, ISSN: 2231-3443,Vol.: 2, Issue.: 1 (January-March)

Original Research Article

Systematic Evaluation on Antioxidant of Magnolol in vitro

 

Xican Li1* and Chan Chen2

1,2School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou Higher Education Mega Center, Guangzhou, China, 510006.

Abstracts

We systematically evaluated in vitro the antioxidant activity of magnolol, a natural phenolic phenylpropanoid, using DPPH (1, 1-Diphenyl-2-picrylhydrazyl radical), ABTS [2, 2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)], Ferric ions (Fe3+) reducing power, superoxide anion and hydroxyl radical-scavenging. In all assays, magnolol and positive controls exhibited effective antioxidant ability. The IC50 values of magnolol were calculated as 25.92, 0.85, 737.56, 29.97, 153.46 μg/mL, respectively, for DPPH, ABTS, Fe3+ reducing power, superoxide anion and hydroxyl radical-scavenging. In these five assays, the IC50 values of Trolox were respectively calculated as 5.08, 2.02, 58.92, 160.26, 62.69 μg/mL, while the IC50 values of BHT were respectively 4.17, 1.76, 75.83, 43.31, 202.64 μg/mL. Furthermore, as DPPH and ABTS assays were conducted in organic solutions, while the other assays were finished in aqueous solutions, magnolol is therefore regarded as an effective antioxidant in vitro in both lipid and aqueous media. Its various protective effects may be attributed to the antioxidant. The fact that magnolol could effectively scavenge both DPPH• and ABTS+• suggested it may exert antioxidant action in vitro by donating hydrogen atom (H•) or electron (e).

Keywords :

Systematic evaluation; magnolol; antioxidant; radical-scavenging; reducing power; in vitro.

Full Article - PDF    Page 68-76

DOI : 10.9734/IRJPAC/2012/628

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