Quick Menu

Upcoming Journals

British Biotechnology Journal

British Biotechnology Journal, ISSN: 2231-2927,Vol.: 4, Issue.: 2 (February)

Original Research Article

Structural Analysis and Docking of Stilbene Synthase Protein from Chinese Grape Vine Vitis pseudoreticulata


K. Divya1, G. Venkata Ramana1 and K. V. Chaitanya1*

1Department of Biotechnology, GITAM Institute of Technology, GITAM University, Visakhapatnam-530045, India.




Aims: The present work aims to perform the molecular modeling of stilbene synthase protein from Chinese grape vine Vitis pseudoreticulata.
Place and Duration of Study: The study has been performed in the Department of Biotechnology, GITAM Institute of Technology, GITAM University, Visakhapatnam, India for a period of 8 months.
Methodology: The sequence of Vitis STS protein was obtained by BLAST search from DFCI web server using Arabidopsis Stilbene synthase sequence. To read the amino acid pattern among these sequences, Multiple Sequence alignment have been performed using clustal W. The secondary and 3D structures were predicted for the protein and the stability of the structures was determined through Ramachandran plot and PROSA analysis. 3D structure obtained using Swiss model workspace was utilized for docking studies.
Results: In the multiple sequence alignment except Gossypium and Ipomea remaining sequences were aligning well. The secondary structure of the protein is possessing helices, coils and sheets respectively and most of the protein structure is coiled. The predicted model was subjected to evaluation by PROSA with a Z score of -10.1. Ramachandran plot revealed that the predicted that 96.6% residues were in favoured region, 2.6% were in allowed region and 0.8% were in outlier region proving that the predicted model is acceptable. Docking STS protein with secondary metabolite ligands elucidated that anethole, ascorbic acid and arbutin have good binding affinity.
Conclusion: The structural model of Vitis pseudoreticulata stilbene synthase has been determined, and in silico docking studies have elucidated that this protein has docked with some of the essential secondary metabolites like anethole, ascorbic acid and arbutin which might enhance the performance when they enter into a biological system.


Keywords :

Stilbene synthase; Vitis pesudoreticulata; molecular modeling; docking.


Full Article - PDF    Page 185-203    Article Metrics


DOI : 10.9734/BBJ/2014/3835

Review History    Comments

Search this site

Advanced Search

Announcement & News

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.