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British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 4, Issue.: 5 (01-15 March)


Antifungal Properties and Chemical Analysis of Essential Oil from Vitex negundo Seeds


Hong-Wei Ai1, Yue-Xin Kang1, Yang Cao1 and Cheng-Jian Zheng1*

1Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.

Article Information


(1) Wenbin Zeng, School of Pharmaceutical Sciences, Central South University, Hunan, China.

(2) Abdelwahab Omri, Department of Chemistry and Biochemistry and Departments of Biomolecular Sciences, Laurentian University, Canada.


(1) Anonymous.

(2) Anonymous.

(3) Anonymous.

(4) Anonymous.

(5) Anthony Babajide Ojekale, Lagos State University, Nigeria.

Complete Peer review History: http://www.sciencedomain.org/review-history/2955


Aims: To investigate the constituents and antimicrobial activity of essential oil from Vitex negundo seeds.
Study Design: The essential oil of Vitex negundo seeds was prepared by hydrodistillation. GC/MS technique was used to determine the volatile constituents in the oil. A total of 13 isolates of bacteria and fungi were employed to evaluate the antimicrobial activity of the oil.
Place and Duration of Study: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, between April 2010 and September 2010.
Methodology: Essential oil from Vitex negundo seeds were obtained by hydrodistillation, with constituents analyzed by GC-MS. Antimicrobial activity of the oil was evaluated against both Gram-positive and Gram-negative bacteria and fungi.
Results: A total of forty-two components, representing 91.36% of the oil, were identified. n-Hexadecanoic acid (17.68%), eudesm-4(14)-en-11-ol (12.39%) and caryophyllene oxide (10.79%) were found to be the major constituents. The essential oil exhibited significant antifungal activity against Candida albicans at MIC 4.0 μg/ml.
Conclusion: The essential oil of Vitex negundo seeds showed potential antifungal activity and can be of potential use in pharmaceutical fields.

Keywords :

Vitex negundo; seeds, essential oil; GC/MS analysis; antifungal.

Full Article - PDF    Page 541-548

DOI : 10.9734/BJPR/2014/7079

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