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British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 4, Issue.: 5 (01-15 March)

Original-research-article

Antifungal Properties and Chemical Analysis of Essential Oil from Vitex negundo Seeds

 

Hong-Wei Ai1, Yue-Xin Kang1, Yang Cao1 and Cheng-Jian Zheng1*

1Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.

Article Information

Editor(s):

(1) Wenbin Zeng, School of Pharmaceutical Sciences, Central South University, Hunan, China.

(2) Abdelwahab Omri, Department of Chemistry and Biochemistry and Departments of Biomolecular Sciences, Laurentian University, Canada.

Reviewers:

(1) Anonymous.

(2) Anonymous.

(3) Anonymous.

(4) Anonymous.

(5) Anthony Babajide Ojekale, Lagos State University, Nigeria.

Complete Peer review History: http://www.sciencedomain.org/review-history/2955

Abstracts

Aims: To investigate the constituents and antimicrobial activity of essential oil from Vitex negundo seeds.
Study Design: The essential oil of Vitex negundo seeds was prepared by hydrodistillation. GC/MS technique was used to determine the volatile constituents in the oil. A total of 13 isolates of bacteria and fungi were employed to evaluate the antimicrobial activity of the oil.
Place and Duration of Study: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, between April 2010 and September 2010.
Methodology: Essential oil from Vitex negundo seeds were obtained by hydrodistillation, with constituents analyzed by GC-MS. Antimicrobial activity of the oil was evaluated against both Gram-positive and Gram-negative bacteria and fungi.
Results: A total of forty-two components, representing 91.36% of the oil, were identified. n-Hexadecanoic acid (17.68%), eudesm-4(14)-en-11-ol (12.39%) and caryophyllene oxide (10.79%) were found to be the major constituents. The essential oil exhibited significant antifungal activity against Candida albicans at MIC 4.0 μg/ml.
Conclusion: The essential oil of Vitex negundo seeds showed potential antifungal activity and can be of potential use in pharmaceutical fields.

Keywords :

Vitex negundo; seeds, essential oil; GC/MS analysis; antifungal.

Full Article - PDF    Page 541-548

DOI : 10.9734/BJPR/2014/7079

Review History    Comments

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