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Cardiology and Angiology: An International Journal, ISSN: 2347-520X,Vol.: 7, Issue.: 4

Original-research-article

Plasma and Erythrocyte Membrane Plasmalogens in Patients with Coronary Heart Diseases Undergoing Percutaneous Intervention

 

Takeshi Arita1, Taku Yokoyama1, Shohei Moriyama1, Kei Irie1, Mitsuhiro Fukata1, Keita Odashiro1, Toru Maruyama1*, Seira Hazeyama2, Shiro Mawatari2, Takehiko Fujino3 and Koichi Akashi1

1Department of Medicine, Kyushu University, Fukuoka 812-8582, Japan.

2Institute of Rheological Function of Foods Co., Ltd., Hisayama 811-2501, Japan.

3BOOCS Clinic, Fukuoka 812-0025, Japan.

Article Information

Editor(s):

(1) Dr. Gen-Min Lin, Division of Cardiology, Hualien-Armed Forces General Hospital, National Defense Medical Center, Taiwan.

Reviewers:

(1) Mra Aye, Melaka Manipal Medical College, Malaysia.

(2) Wang Jie, Guanganmen Hospital, China Academy of Chinese Medical Sciences, China.

Complete Peer review History: http://www.sciencedomain.org/review-history/26742

Abstracts

Aims: Plasmalogens are unique phospholipid of biological membrane and is considered to play a potent role of intrinsic antioxidant. Atherosclerosis is associated with oxidative stress, but the correlation between plasmalogens and atherosclerosis is debatable. Therefore, this study aimed to assess the plasma and erythrocyte membrane phospholipids profile in patients with coronary heart diseases (CHD) undergoing percutaneous coronary intervention (PCI).

Place and Duration of the Study: Vascular laboratory of Heart Center, Kyushu University Hospital, Fukuoka, Japan, from February to August 2016.

Methodology: The plasma concentrations and erythrocyte membrane contents of phospholipids were quantified in patients with CHD (n = 30, group A) and age-matched controls (n = 38, group B) using high-performance liquid chromatography with evaporative light scattering detection method. Results: Plasma concentrations of plasmalogens in group A were significantly lower than those in group B. Similar findings were obtained from relative contents of plasmalogens in the erythrocyte membrane. Multiple regression models for plasmalogens yielded phospholipids other than plasmalogen as determinants of plasmalogens.

Conclusions: This cross-sectional study indicated that plasma and erythrocyte membrane plasmalogens are reduced in patients with CHD undergoing PCI. Further longitudinal studies are required to elucidate the clinical role of intrinsic plasmalogens as a laboratory marker of oxidative stress and extrinsic plasmalogens as a novel therapy for atherosclerosis.

Keywords :

Coronary heart disease; percutaneous coronary intervention; erythrocyte membrane; plasmalogens.

Full Article - PDF    Page 1-11

DOI : 10.9734/CA/2018/44602

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