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Journal of Advances in Medicine and Medical Research, ISSN: 2456-8899, ISSN: 2231-0614 (Past),Vol.: 27, Issue.: 6


A Comparative Study of Time Dependent Candidal Colonisation in Diabetic and Non-diabetic Complete Denture Patients


Mujtaba Ashraf1, Mariyam Ali1, Abhishek Gaur1, Monika Rajani1, A. K. Verma1, Pratibha Katiyar1, Kaushik Kumar Pandey1* and Fauzia Tarannum1

1Department of Prosthodontics, Career Post Graduate Institute of Dental Sciences, Lucknow, India.

Article Information


(1) Dr. Mohamed Essa, Department of Food Science and Nutrition, Sultan Qaboos University, Oman.


(1) Adam Husein, University of Science, Malaysia.

(2) Renata Souto, Federal University of Rio de Janeiro, Brazil.

(3) Reginaldo dos Santos Pedroso, Federal University of Uberlândia, Brazil.

Complete Peer review History:


Introduction: Acrylic dentures are important predisposing factors for oral candidiasis. Duration of wearing dentures in the oral cavity of diabetic and non-diabetic patients can increase Candida colonisation and results in the higher incidence of oral and systemic candidiasis.

Aims and Objective: 1. To compare the changes in Candidal colonisation with time in complete denture prosthesis in diabetics and non-diabetics. 2. To evaluate the change in Candidal growth in diabetics and non-diabetic complete denture wearers. 3. To evaluate the relation of time with Candidal growth in complete denture wearers.

Materials and Methods: Three Salivary samples from each 20 edentulous, non-insulin dependent diabetic and 20 edentulous (Group-1), non-diabetic subjects (Group-2) were collected at 3 different time intervals. First sample was collected on the day of denture insertion, the second sample after one week from the day of insertion and third sample, after one month from the day of denture insertion in sterile containers using oral rinse technique. All samples were cultured directly on Sabouraud agar medium and species identification was done by HiCrome Candida Differential Agar culture methods.

Results: Candidal carriage and colonisation is more in diabetic denture wearer patients than non- diabetic denture wearer patients. Candidal growth in complete denture wearers was significantly increased from Day 1 to last day of 1st week (p=0.006), Day 1 to last day of 1st Month (p=0.005) and last day of 1st Week to last day of 1st Month (p=0.007) in Group 1. There was significant mean change in Group 2 from last day of 1st Week to last day of 1st Month (p=0.001). The common species of Candida isolated in both diabetic and non-diabetic denture wearer patients are: C. albicans, C. glabrata and C. tropicalis.

Keywords :

Candidal colonisation; complete dentures; diabetes mellitus.

Full Article - PDF    Page 1-8

DOI : 10.9734/JAMMR/2018/43719

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