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International Research Journal of Pure and Applied Chemistry

International Research Journal of Pure and Applied Chemistry, ISSN: 2231-3443,Vol.: 1, Issue.: 3 (October-December)

 

Original Research Article

 

Synthesis of Some Novel Bis 1,3,4-Oxadiazole Fused Azo Dye Derivatives as Potent Antimicrobial Agents 

 

 

A. H. Shridhar1, J. Keshavayya1*, H. Joy Hoskeri2 and R. A. Shoukat Ali2

1Department of Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri Shankaraghatta – 577 451, India.
2Department of Studies and Research in Biotechnology, School of Bio-Sciences, Kuvempu University, Jnana Sahyadri Shankaraghatta – 577 451, India.

 

Abstracts

 

3,5-bis(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)azo dyes were synthesized by multistep reaction sequences, which is diazotized and coupled with different napthols and quinoline. Structure of newly synthesized compounds were characterized and confirmed by IR, NMR and Mass spectral studies. The newly synthesized azo dye fused with (5-(furan-2-yl)-1,3,4-oxadiazole) were screened for their acute toxicity and gross behavioral studies and in-vitro anti-microbial activity. Synthesized compounds exhibit significant biological activity and can certainly hold greater promise in discovering safer biologically active molecules.

 

Keywords :

3,5-bis(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl) azo dyes; Anti-microbial activity; Acute toxicity and gross behavioral studies;

 

Full Article - PDF    Page 119-129    Article Metrics

 

DOI : 10.9734/IRJPAC/2011/493

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