Journal of Applied Life Sciences International, 2394-1103,Vol.: 18, Issue.: 2
A Review on the Evolutionary Trajectories of mRNA BRCA1/2 Genes in Primates and the Implications of Cancer Susceptibility Variants within Immediate Human Populations
Tommy Rodriguez1* 1Pangaea Biosciences, Department of Research and Development, Miami, Florida, USA.
1Pangaea Biosciences, Department of Research and Development, Miami, Florida, USA.
(1) Malakeh. Z. Malak, Community Health Nursing, Al-Zaytoonah University of Jordan, Jordan.
(1) Jose Carlos Rosa Pires De Souza, Mato Grosso Do Sul State University, Brazil.
(2) Bruno Ricardo Barreto Pires, Instituto Nacional de Câncer, Brazil.
(3) Jennifer Schroeder, Millikin University, USA.
Complete Peer review History: http://www.sciencedomain.org/review-history/25865
Researchers have shown that cancer susceptibility in BRCA1/2 occurs at disproportional rates and statistical degrees across a wide range of species, particularly non-human primates. This study incorporates two primary scopes for examining BRCA 1/2 cancer susceptibility among closely related lineages: (1) phylogenetic reconstruction of mRNA BRCA1/2 genes (both cancer susceptible and non-cancer susceptible) in variously distinct primate families (including Homo sapiens); and (2) pairwise comparative analysis of breast cancer 1 early onset BRCA1 mRNA partial cds within immediate human populations. The results generated by phylogenetic reconstruction together with pairwise comparative analysis revealed that cancer-causing alterations in BRCA1/2 appear to originate within localized gene pools at separate junctures throughout evolutionary time. This supports the explanation that BRCA1/2 genes may be undergoing rapid evolution, as revealed by unusually high proportion of dissimilarities between cancer susceptibility sequences among members of each group or species.
Breast cancer; ovarian cancer; phylogenetics; multiple sequence alignment; pairwise sequence alignment; BRCA genes.
DOI : 10.9734/JALSI/2018/43129Review History Comments
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