Quick Menu

Upcoming Journals

Journal of Applied Life Sciences International

Journal of Applied Life Sciences International, 2394-1103,Vol.: 18, Issue.: 2

Original-research-article

A Review on the Evolutionary Trajectories of mRNA BRCA1/2 Genes in Primates and the Implications of Cancer Susceptibility Variants within Immediate Human Populations

 

Tommy Rodriguez1*

1Pangaea Biosciences, Department of Research and Development, Miami, Florida, USA.

 

Article Information

Editor(s):

(1) Malakeh. Z. Malak, Community Health Nursing, Al-Zaytoonah University of Jordan, Jordan.

Reviewers:

(1) Jose Carlos Rosa Pires De Souza, Mato Grosso Do Sul State University, Brazil.

(2) Bruno Ricardo Barreto Pires, Instituto Nacional de Câncer, Brazil.

(3) Jennifer Schroeder, Millikin University, USA.

Complete Peer review History: http://www.sciencedomain.org/review-history/25865

 

Abstracts

 

Researchers have shown that cancer susceptibility in BRCA1/2 occurs at disproportional rates and statistical degrees across a wide range of species, particularly non-human primates. This study incorporates two primary scopes for examining BRCA 1/2 cancer susceptibility among closely related lineages: (1) phylogenetic reconstruction of mRNA BRCA1/2 genes (both cancer susceptible and non-cancer susceptible) in variously distinct primate families (including Homo sapiens); and (2) pairwise comparative analysis of breast cancer 1 early onset BRCA1 mRNA partial cds within immediate human populations. The results generated by phylogenetic reconstruction together with pairwise comparative analysis revealed that cancer-causing alterations in BRCA1/2 appear to originate within localized gene pools at separate junctures throughout evolutionary time. This supports the explanation that BRCA1/2 genes may be undergoing rapid evolution, as revealed by unusually high proportion of dissimilarities between cancer susceptibility sequences among members of each group or species.

 

Keywords :

Breast cancer; ovarian cancer; phylogenetics; multiple sequence alignment; pairwise sequence alignment; BRCA genes.

 

Full Article - PDF    Page 1-8    Article Metrics

 

DOI : 10.9734/JALSI/2018/43129

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...



SCIENCEDOMAIN Awards

  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.