International Blood Research & Reviews, ISSN: 2321-7219,Vol.: 2, Issue.: 1 (January-February)
Prostate Specific Antigen (PSA) Screening among Apparently Healthy Men of African Descent in Sokoto, North Western, Nigeria
O. Erhabor1, Isaac Zama1, A. S. Mainasara1, R. A. Shehu2, I. P. Iwueke3, Aghedo Festus4 , D. Ikhuenbor4 , E. K. Uko5 and O. O. Igbineweka6 1Faculty of Medical Laboratory Science Usmanu Danfodio University Sokoto, Nigeria.
2Department of Biochemistry Usmanu Danfodio University Sokoto, Nigeria.
3Pathology Department, Federal Neuro Psychiatric Hospital Kware, Sokoto, Nigeria.
4Department of Haematology and Transfusion Medicine Usmanu Danfodio University Teaching Hospital Sokoto, Nigeria.
5Department of Haematology, University of Calabar, Nigeria.
6One Brigade Medical Centre Sokoto, Nigeria.
O. Erhabor1, Isaac Zama1, A. S. Mainasara1, R. A. Shehu2, I. P. Iwueke3, Aghedo Festus4 , D. Ikhuenbor4 , E. K. Uko5 and O. O. Igbineweka6
1Faculty of Medical Laboratory Science Usmanu Danfodio University Sokoto, Nigeria.
(1) Dharmesh Chandra Sharma, Incharge Blood Component & Aphaeresis Unit, G. R. Medical College, Gwalior, India.
Complete Peer review History: http://www.sciencedomain.org/review-history/2585
Background: Globally prostate cancer is the sixth leading cause of cancer-related death in men. Prostate Specific Antigen (PSA) is present in small amount in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer and other prostate-related disorders. The aim of this present study was to determine the PSA levels among healthy men of African descent resident in Sokoto, North Western Nigeria.
Methods: Testing was carried out using the CTK Biotech PSA kit (CTK Biotech Inc, San Diego, USA). The Onsite PSA Rapid Test is a lateral flow chromatographic immunoassay for the qualitative detection of prostate specific antigen (PSA) in human serum or plasma at a cut-off level of 4.0 ng/mL.
Result: We investigated the PSA levels in 106 consecutively recruited men of African descent with age range and mean age of 40-70 years and 44.75 ± 7.91 years respectively. We observed a PSA of > 4ng/mL among 7 (6.6%) of subjects studied. Men > 60 had the highest prevalence of raised PSA level (33.3%) compared to those younger men (p= 0.001). We observed a higher prevalence among farmers (11.1%) compared to business men, civil servants and students.
Conclusion: In this present study we observed a high prevalence of PSA >4ng/mL and a positive and significant correlation between age and raised PSA levels among men in Sokoto, North Western Nigeria. We recommend an annual PSA blood test for men ≥ 40 years of age and that those with a PSA value > 4.0 ng/mL should be considered for further evaluation. There is also the need to build capacity among biomedical and medical staff in Nigeria to facilitate effective diagnosis of prostate cancer. There is also the need for increased prostate cancer awareness in the area to facilitate voluntary testing.
Prostate specific antigen (PSA); apparently healthy men; Sokoto; Nigeria.
Full Article - PDF Page 37-47
DOI : 10.9734/IBRR/2014/6362Review History Comments