Quick Menu

Upcoming Journals

International Journal of Biochemistry Research & Review

International Journal of Biochemistry Research & Review, ISSN: 2231-086X,Vol.: 23, Issue.: 1


Nutrients and Constituents Relevant to Antioxidant, Antimicrobial and Anti-Breast Cancer Properties of Salvia officinalis L.


Amira M. G. Darwish1*, Gamal M. Hamad1 and Sobhy A. El Sohaimy1

1Department of Food Technology, Arid Lands Cultivation Research Institute (ALCRI), City of Scientific Research and Technological Applications (SRTA-City), 21934, Alexandria, Egypt.


Article Information


(1) Halit Demir, Professor, Department of Chemistry, Faculty of Art and ScienceYuzuncu, Yil University, Turkey.


(1) Deepshikha Kushwaha, Sam Higginbottom Institute of Agriculture, Technology and Sciences, India.

(2) A. Papazafiropoulou, Tzaneio General Hospital of Piraeus, Greece.

(3) Ana Maria Loureiro da Seca, University of Azores, Portugal.

Complete Peer review History: http://www.sciencedomain.org/review-history/25820




Objective: Comprehensive assessment of the chemical composition of sage leaves (Salvia officinalis L.) in order to highlight constituents relevant to the antioxidant, antimicrobial and anticancer potentials, in addition to determining safe dose to facilitate its application in functional foods and dairy products.

Methods: High-Performance Liquid Chromatography (HPLC) was employed to determine constituents such as amino acids, fatty acids and phenolic compounds content. Antioxidant activity was characterized using, α- diphenyl-β-picrylhydrazyl (DPPH) and reducing power methods. The antimicrobial potentials were examined against nine pathogenic strains. MDA-MB-231 cell line was used to assess anticancer activity.

Results: Sage was found to be a good source of calcium, iron and zinc (894.3, 84 and 5.5 mg/100 g respectively) and vitamins B6 and B12 (1.5 and 0.3 mg/100 g respectively). Performed HPLC analysis indicated the rich content of essential amino acids, lysine, phenylalanine and leucine (10.4, 0.7 and 0.45 g/100 g), unsaturated fatty acids, Omega 3, 6 and 9 (6.46, 4.40 and 3.13 g/100 g) and phenolic compounds, quercetin and cinnamic (604.8 and 390.4 μg/mL), which interpreted its high antioxidant powers. Sage revealed antioxidant potentials with IC50 and EC50 reached (27.5 and 239.5 mg/mL respectively), and antimicrobial effect against the examined pathogenic strains with MICs reached 6.25 mm against Staph. aureus, E. coli and Candida albicans, not to mention its anticancer effect as an extra pharmacological feature, when sage performed an anti-proliferative activity with IC50 of 300 µg/mL, against MDA-MB-231 cell line.

Conclusion: Obtained results emphasis the sage leaves content of variable nutrients and active compounds that reflected on its vast nutritional and pharmacological potentials such as; antioxidant, antimicrobial and cytotoxic effect against breast MDA-MB-231 cell line, that could nominate it as applicable food bio-preservative in functional foods and dairy products.


Keywords :

Sage (Salvia officinalis); HPLC; antioxidant potentials; antimicrobial properties; MDA-MB-231 cell line.


Full Article - PDF    Page 1-13    Article Metrics


DOI : 10.9734/IJBCRR/2018/43273

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.