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Journal of Advances in Medical and Pharmaceutical Sciences, 2394-1111,Vol.: 17, Issue.: 3

Original-research-article

Mitigations in Selected Hemostatic Parameters in Administration of Graded Doses of Dexamethasone and Its Blockers on Wistar Rats 

 

E. K. Nwangwa1*, E. I. Ekhoye2, E. N. Ekene3 and M. O. Oyovwi1

1Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.

2Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Edo University, Iyamho, Edo State, Nigeria.

3Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.

Article Information

Editor(s):

(1) Dr. Jinyong Peng, Professor, College of Pharmacy, Dalian Medical University, Dalian, China.

Reviewers:

(1) Nissar Shaikh, Qatar.

(2) Nagahito Saito, Japan.

Complete Peer review History: http://www.sciencedomain.org/review-history/25491

Abstracts

Clinical trials have shown that an even newer compound, Dexamethasone (Dex.), might be more potent and less likely to cause side-effects than any other known corticosteroid medication. This study investigated the possible changes in selected hemostatic parameters [clotting time, bleeding time, platelets count and fibrinogen level] in albino wistar rats, following administration of graded doses of Dex. Forty-two (42) male albino Wistar rats were randomly grouped into seven (7) of six (6) rats each. With Group A receiving normal diets (Control), Groups B – G were respectively given 0.1 mg/Kg of Dex, 0.3 mg/Kg of Dex, 0.1 mg/Kg of Dex + 33 mg/Kg of Ketokonazol (Keto), 0.3 mg/Kg of Dex + 33 mg/Kg of Keto, 0.1 mg/Kg of Dex + Vitamin (Vit.) E and 0.1 mg/Kg of Dex. + Vit E. following two-weeks administration period, rats were euthanized and blood samples obtained by cardiac puncture under diethyl ether to determine hemostatic parameters. One-way Analysis of Variance (ANOVA) revealed that Dex, in higher doses decreased bleeding and clotting time, with significant increase (p < .05) in platelet and fibrinogen counts. However, Vitamin E and Ketoconazole treatment reversed this effect by increasing bleeding and clotting time withdecreased fibrinogen levels and platelet count. Thus, study demonstrates that Dexamethasone affect hemostasis by significantly decreasing bleeding and clotting times, and also enhances hemostatic function with significant increase in fibrinogen and platelet count which may predispose to thrombotic disorders.

Keywords :

Dexamethasone; hemostasis; ketoconazole; vitamin E.

Full Article - PDF    Page 1-7 Article Metrics

DOI : 10.9734/JAMPS/2018/41654

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