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Annual Research & Review in Biology, ISSN: 2347-565X,Vol.: 27, Issue.: 4

Original-research-article

Effect of Age and Pre-ovulatory Estradiol2 Levels on Endometrial Thickness and Number of Dominant Follicles for Women with Polycystic Ovary Syndrome Subjected to Ovulation Induction Protocols

 

Sundus Fadhil Hantoosh1*, Farah T. O. Al-Jumaili2, Dheaa Shamikh Zageer3 and Mayyahi Mohammad T. Jaber3

1Department of Training and Development, DNA Forensic Center for Research and Training, Al-Nahrain University, Baghdad, Iraq.

2Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq.

3DNA Forensic Center for Research and Training, Al-Nahrain University, Baghdad, Iraq.

Article Information

Editor(s):

(1) Dr. Saramma George, Human Physiology, Department of Biomedical Sciences, Faulty  of Medicine, University of Botswana, Botswana.

(2) Dr. George Perry, Dean and Professor of Biology, University of Texas at San Antonio, USA.

Reviewers:

(1) Juliano Brum Scheffer, Brazilian Institute of Assisted Reproduction, Brazil.

(2) Ivanova Liudmila, Kuban State Medical University, Russia.

(3) Nirvana Samy, Egypt.

Complete Peer review History: http://www.sciencedomain.org/review-history/25477

Abstracts

Introduction: Intrauterine insemination (IUI) is the first line of treatment in assisted reproductive technology. Oocyte quality and endometrial thickness are the main predictors of IUI pregnancy outcomes.

Materials and Methods: thirty-one infertile polycystic ovarian syndrome women were enrolled in this study. All study cases were subjected to either administration of clomiphene citrate only or combination of clomiphene citrate and injectable follicle-stimulating hormone protocols. Pre-ovulatory estradiol2 (E2) levels, pre-ovulatory endometrial thickness, and number of dominant follicles were measured.

Results: Significant relationship was between age and number of dominant follicles (p=0.0001). Significant relationship was between number of dominant follicles and pre-ovulatory endometrial thickness (p=0.0001). No significant increase was in mean pre-ovulatory E2levels in age group women (≤32 years) compared to age group women (>32 years) (p=0.384). Significant effect of pre-ovulatory E2 levels were on endometrial thickness and number of dominant follicles (p=0.0382, p=0.0377, respectively). Significant correlation was between the three factors age, pre-ovulatory E2, and number of dominant follicles (p=0.0297). No significant correlation was between the three factors age, pre-ovulatory E2 levels, and endometrial thickness (p=0.081).

Conclusions: age and pre-ovulatory E2 levels had considerable impacts on number of dominant follicles and endometrial thickness and consequently affected IUI outcomes.

Keywords :

Age; estradiol; endometrium; dominant follicles.

Full Article - PDF    Page 1-10 Article Metrics

DOI : 10.9734/ARRB/2018/42475

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