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Journal of Advances in Medicine and Medical Research, ISSN: 2456-8899, ISSN: 2231-0614 (Past),Vol.: 27, Issue.: 1

Review Article

Leptomeningeal Carcinomatosis as a Presentation of Relapse in Adenocarcinoma of Colon: A Case Report and Review


Ramchandani Santosh1, Ashish Manne1, Ankit Madan1 and Ravi Kumar Paluri1*

1Hematology Oncology Division, Department of Internal Medicine, University of Alabama, Birmingham, USA.

Article Information


(1) Dr. Evangelos Marinos, Associate Professor, University of Athens, School of Medicine, Laboratory of Biology, Athens, Greece.


(1) Keiki Nagaharu, Mie University Hospital, Japan.

(2) Tariq Namad, Hospital Military Instruction Mohamed V, Morocco.

Complete Peer review History:


The incidence of leptomeningeal carcinomatosis (LC) has been increasing, due to advances in the cancer and the improved overall survival of cancer patients. Breast and lung cancer are the most frequently reported causes of LC among solid tumors. LC occurs very rarely in patients with colon cancer. Leptomeningeal carcinomatosis is characterized by multifocal seeding of the leptomeninges by malignant cells that originate from a solid tumor. The median survival of untreated patients is 4 to 6 weeks. Although the diagnosis may be challenging, an early treatment before the setting of neurological deficits is required in order to improve the clinical outcomes. The treatment requires a multidisciplinary approach by a combination of chemotherapy and targeted therapies administrated systemically or via intra-cerebrospinal fluid route, surgery and radiotherapy. Here, we describe a case of leptomeningeal carcinomatosis in which the primary tumor was colon cancer that has progressed to LC but responded significantly to our treatment strategy. Also, we review the literature on carcinomatosis in solid tumors.

Keywords :

Leptomenineal carcinomatosis; meningeal carcinomatosis; colon cancer with brain metastasis; CNS metastasis in solid tumors.

Full Article - PDF    Page 1-6

DOI : 10.9734/JAMMR/2018/41738

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