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Journal of Advances in Medicine and Medical Research, ISSN: 2456-8899, ISSN: 2231-0614 (Past),Vol.: 26, Issue.: 11


Correlation among Biochemical Profile Markers and Diagnostic Value of Uric Acid Level to Differentiate between Glucose Abnormalities


Elham Kalantari1, Bizhan Iraj2, Khosro Taei1* and Masoud Amini3

1Department of Internal Medicine, Isfahan University of Medical Science, Isfahan, Iran.

2Department of Endocrinology, Isfahan University of Medical Science, Isfahan, Iran.

3Department of Endocrinology, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Science, Isfahan, Iran.

Article Information


(1) E. Umit Bagriacik, Department of Immunology, Gazi University, Turkey.


(1) Nazan Uysal, Dokuz Eylul University, Turkey

(2) Arrigo F. G. Cicero, University of Bologna, Italy.

(3) Vladimíra Tomečková, University of Pavol Jozef Šafárik, Slovakia.

Complete Peer review History:


Aims: The current study aims to compare the relationship among uric acid level, fasting blood glucose, 2-hour glucose, HbA1C and diagnostic value of uric acid level with diabetes and Pre-diabetes in healthy people and patients with pre-diabetes and diabetes.

Study design:  It is a descriptive – analytical study.

Methodology: This study composed of a total of 1080 participants classified into three groups (n = 360) including healthy people (HbA1C<5.6 and fasting plasma glucose<100 mg/dl), prediabetic (5.7%≤ HbA1C<6.5% and 100 mg/dl < fasting plasma glucose < 126 mg/dl) and diabetic patients (HbA1C≥6.5 and fasting plasma glucose ≥126 mg/dl) presented at Endocrinology and Metabolism Research Center in Isfahan, during 2008 – 2013. The parameters including gender, BMI, blood pressure, fat level, fasting plasma glucose, 2-hour postload glucose, HbA1C and serum uric acid were recorded and analyzed with SPSS (Ver. 20).

Results: Mean uric acid levels of healthy, prediabetic and diabetic groups were 4.89±1.37 mg/dl , 5.21±1.29 mg/dl and 5.01±1.44 mg/dl respectively, indicating a significantly higher level in prediabetic group (P<0.001). Blood sugar levels had a significant increase in healthy people (P<0.001) compared to other groups. Serum uric acid was positively correlated with fasting plasma glucose and HbA1C in general but weak in prediabetic and healthy subjects versus a negative correlation in the diabetic group. In addition, serum uric acid cut-off (≥4.75 mg/dl) can be a good diagnostic criterion for pre-diabetes prediction compared with normal people (P<0.05).

Conclusion: Although serum uric acid is not a target for the treatment of asymptomatic hyperuricemia and not a risk marker of clinical activities, it may be considered as a new therapeutic target for prevention of diabetes or its progression.

Keywords :

Pre Diabetes; diabetes; serum uric acid; 2-hour Post load Glucose; fasting plasma Glucose; HbA1C.

Full Article - PDF    Page 1-9

DOI : 10.9734/JAMMR/2018/41276

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