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European Journal of Medicinal Plants, ISSN: 2231-0894,Vol.: 24, Issue.: 1


Effect of Hydroalcoholic Extract of Some Medicinal Plants on Obesity


Majid Ramezani1, Saeed Changizi-Ashtiyani1,2*, Firoozeh Sadeghzadeh3, Seyed-Sirvan Hosseini4, Ali Zarei5 and Naser Hosseini6

1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

2Department of Physiology, Arak University of Medical Sciences, Arak, Iran.

3Department of Biology, Arak University of Medical Sciences, Arak, Iran.

4Student Research Committee, Arak University of Medical Sciences, Arak, Iran.

5Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran.

6Department of Medicinal Plants, Arak University, Arak, Iran.

Article Information


(1) Daniela Rigano, Department of Chemistry of Natural Compounds, University Federico II of Naples, Italy.

(2) Marcello Iriti, Professor, Plant Biology and Pathology, Department of Agricultural and Environmental Sciences, Milan State University, Italy.


(1) Nadia A. Rojano Vilchis, National Autonomous University of Mexico, México.

(2) Veeravan Lekskulchai, Srinakharinwirot University, Thailand.

(3) Papiya Bigoniya, RKDF University, India.

(4) Mohammed Kawser Hossain, Sylhet Agricultural University, Bangladesh.

Complete Peer review History: http://www.sciencedomain.org/review-history/25187


Aims: Obesity is a significant cause of disability and death. This study was conducted to evaluate the efficacy of some medicinal plants in the treatment of obesity and its complications.

Study Design: Male Wistar rats were treated in different groups.

Place and Duration of Study: Department of Physiology, Arak University of Medical Sciences (Iran), December 2015 to July 2017.

Methodology: The groups were defined as the control, the high-fat diet and the high-fat diet with hydroalcoholic extracts of Camellia sinensis, Rosa canina, Althaea officinalis, Plantago major and Orlistat in their food, for 48 days. In the serum, the profiles of the liver enzymes and the thyroid hormones were measured as parameters of their appetite.

Results: The lowest increase in appetite happened in the Camellia sinensis group and the lowest levels of blood glucose and creatinine were in the Plantago primary group. The lowest cholesterol and low-density lipoprotein (LDL) were seen in the Camellia sinensis group (P<0.05). The amount of alanine aminotransferase (ALP) and the level of aspartate aminotransferase (AST) in the Plantago major group were significantly lower than the positive control group (P<0.05). In Althaea officinalis group were higher Orlistat and alkaline phosphatase (ALP) than the control group (P<0.05). The level of thyroid-stimulating hormone (TSH) in control group was significantly lower than the positive control, Camellia sinensis and Rosa canina groups (P<0.05). The level of thyroxin in Althaea officinalis, Rosa canina and Camellia sinensis groups were significantly lower than the positive control group, respectively (P<0.05).

Conclusion: Hydroalcoholic extracts of Camellia sinensis, Rosa canina, Althaea officinalis, and Plantago major are effective in reducing the damages caused by high-fat diet through decreasing lipid profiles, liver enzymes, without causing side effects on thyroid and renal functions.

Keywords :

Obesity; Camellia sinensis; Althaea officinalis; Rosa canina; Plantago major.

Full Article - PDF    Page 1-10 Article Metrics

DOI : 10.9734/EJMP/2018/41111

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