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International Blood Research & Reviews, ISSN: 2321-7219,Vol.: 8, Issue.: 2

Original-research-article

Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Neonates in Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto, Nigeria: Oxidative Stress Markers in G6pd Deficient Neonates

 

Taofeeq Oduola1*, Faruq Bunza1, Monsurat Temitope Yusuf1, Muhammed Kabiru Dallatu1, Muhammed Alhaji Ndakotsu2, Abubakar Panti3, Ben Onankpa4 and Adesoji Adeniji5

1Department of Chemical Pathology, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.

2Department of Haematology and Blood Transfusion, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.

3Department of Obstetrics and Gynaecology, Faculty of Surgery, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.

4Department of Paediatrics, Faculty of Medicine, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.

5Department of Chemical Pathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

Article Information

Editor(s):

(1) Anamika Dhyani, Laboratory of Biochemistry & Molecular and Cellular Biology, Hemocentro-UNICAMP, Brazil.

(2) Dharmesh Chandra Sharma, Incharge Blood Component & Aphaeresis Unit, G. R. Medical College, Gwalior, India.

(3) Armel Herve Nwabo Kamdje, Professor, Department of Biomedical Sciences, University of Ngaoundere, Cameroon.

Reviewers:

(1) Jaime Carmona-Fonseca, Universidad de Antioquia, Colombia.

(2) Hadiza Abdullahi, North West University, Nigeria.

(3) Dhastagir Sheriff, Benghazi University, Libya.

Complete Peer review History: http://www.sciencedomain.org/review-history/25133

Abstracts

Background: Glucose-6-phosphate dehydrogenase deficiency is one of the most common enzyme defects affecting all races and particularly in malaria-endemic areas. This study aimed at determining G6PD deficiency, bilirubin and oxidative stress biomarkers in G6PD deficient neonates among neonates in UDUTH, Sokoto.

Methods: Samples of cord blood were collected at delivery, in the Labour Room, from 300 neonates made up of 131 (43.7%) males and 169 (56.3%) females. Methaemoglobin reduction method was used for the screening of G6PD deficiency; total bilirubin level was estimated using bilirubinometer, total antioxidant capacity (TAC) was measured using TAC Assay Kit, and malondialdehyde (MDA) using thiobarbituric acid method. 

Results: Of the 300 neonates tested, a total of 90(30%) were G6PD-deficient while 210(70%) had normal G6PD status. Of the 90 G6PD-deficient neonates, 41(45.6%) were males and 49(54.4%) were females. The prevalence was 31.3% among male population and 29.0% among female population. The mean ± standard error of total bilirubin (mg/dL), TAC (uM CRE), and MDA (nmol/L) in G6PD-deficient and G6PD-normal neonates were 6.63 ± 0.12 and 6.11 ± 0.06, 364.34 + 18.76 and 390.99 + 24.18, 26.15 + 1.22 and 23.35 + 1.15 respectively. The total bilirubin was significantly higher (p<0.05) in G6PD-deficient neonate than in G6PD-normal neonates, both TAC and MDA values showed no significant difference between the G6PD deficient and G6PD normal neonates.

Conclusion: From this study, there is a high prevalence of G6PD deficiency among neonates in UDUTH, Sokoto. G6PD deficiency is a known cause of neonatal jaundice hence it is recommended G6PD screening be made routine for all neonates born in UDUTH, Sokoto.

Keywords :

G6PD; prevalence; lipid peroxidation; bilirubin; neonatal jaundice.

Full Article - PDF    Page 1-6

DOI : 10.9734/IBRR/2018/42009

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