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Journal of Advances in Microbiology, 2456-7116,Vol.: 11, Issue.: 1

Original-research-article

Assessment of Antiplasmodial and Anti-anaemic Activities of Hoslundia opposita, an Ivorian Medicinal Plant

 

Karamoko Chérif Moustapha1,2, Tuo Karim2*, Toure André Offianan2, Beourou Sylvain2, Attemene Dago Serge David1,2, Gnondjui Alloh Albert1,2, Yao Serge Stéphane1,2 and Bidie Alain Dit Philippe1

1University of Felix Houphouet Boigny, 22 P.O.Box 582 Abidjan 22, Côte d’Ivoire.

2Institut Pasteur of Côte d’Ivoire, 01 P.O.Box 490 Abidjan 01, Côte d’Ivoire.

Article Information

Editor(s):

(1) Adekunle Sanyaolu, Epidemiology Division, Nigeria Center for Disease Control, Federal Ministry of Health, Abuja, Nigeria.

Reviewers:

(1) Morebise, Olugbenga, Al Saints University School of Medicine, Dominica.

(2) Voravuth Somsak, Walailak University, Thailand.

Complete Peer review History: http://www.sciencedomain.org/review-history/25096

Abstracts

Aims: The aim of this study was to investigate the antiplasmodial and anti-anaemic activities of different extracts of Hoslundia opposita

Place and Duration of Study: This study was carried out from March to November at Institut Pasteur of Côte d’Ivoire.

Methodology: Extracts of Hoslundia opposita were prepared using various solvents. The in vitro antiplasmodial activity was investigated on both clinical isolates and Chloroquine-resistant K1 strain of Plasmodium falciparum, using SYBR green I based assay. Moreover, the anti-anaemic activity was assessed on phenyl hydrazine induced anaemia in albino rats.

Results: Two (2) among the five (5) extracts were not active. However, the hydroethanolic, aqueous and ethyl acetate extracts exhibited a moderate (IC50= [22.88 – 49.65] μg/mL), promising (IC50=[5.99 – 12.1] μg/mL), and very active (IC50= 1.57 μg/mL) on clinical isolates. The hydroethanolic and aqueous extracts showed a promising antiplasmodial activity (IC50= 11.68 and 12.23 μg/mL respectively) on Chloroquine-resistant K1 strain of P. falciparum. Whereas, the ethyl acetate extract exhibited a potent activity (IC50= 0.78 μg/mL) on it. Extract showing good antiplasmodial activity were used for in vivo anti-anaemic test. Among selected extracts, the hydroethanolic extract was the most active with hematologic recovery percentages better than those of vitamin B12.

Conclusion and Prospect: Hoslundia opposita could be a potential source for new antimalarial drugs. Furthermore, this plant extract might be used as an improved traditional medicine.

Keywords :

Plasmodium falciparum; Hoslundia opposite; chemosensitivity.

Full Article - PDF    Page 1-11 Article Metrics

DOI : 10.9734/JAMB/2018/41897

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