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International Blood Research & Reviews, ISSN: 2321-7219,Vol.: 8, Issue.: 2

Original-research-article

Normal CD4 Count in Healthy Voluntary Blood Donors in the Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan

 

Tshokey Tshokey1*, Tashi Choden1, Kinley Wangchuk1, Tshering Yangdon2, Tshering Lhagay1, Pema Kuenzang1, Jamyang Wangmo1, Binita Rai1 and Tashi Yangzom2

1Microbiology Unit, Department of Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.

2Blood Bank Unit, Department of Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.

Article Information

Editor(s):

(1) Mehmet Sonmez, Professor, Department of Haematology, School of Medicine, Karadeniz Technical University, Turkey.

Reviewers:

(1) Ashok Pandey, Nepal.

(2) Emeka Ejeliogu, University of Jos, Nigeria.

Complete Peer review History: http://www.sciencedomain.org/review-history/25079

Abstracts

Aim: This study aimed to estimate the normal CD4 counts in healthy Bhutanese blood donors.

Study Design: A prospective descriptive study.

Place and Duration of Study: This study was carried out in the Jigme Dorji Wangchuck National Referral Hospital (JDWNRH), Thimphu, between July 2015 to April 2016.

Methodology: We recruited healthy blood donors in the JDWNRH collecting demographic characters and blood samples from consenting donors. Blood samples were analyzed using the BD FACS count system.

Results: A total of 413 healthy blood donors, 288 (69.7%) males with a mean age of 27.3 years (18-62 years) were enrolled.  Ethnically, 351 (85.0%) were northern and 62 (15.0%) were southern Bhutanese. The mean CD4 count was 668.3 cells/µl (range 259 -1591 cells/µl) and the median was 663 cells/µl.  Females had significantly higher counts (p=0.004) and CD4 counts also significantly increased with increasing age but these differences were numerically small. Ethnicity did not produce significant differences in the CD4 count. In about 21% of the participants, counts were below the reference ranges and published data for Indians and Caucasians but comparable to other Asian, Middle East and African population. 

Conclusion: Upon validation with a larger study, a somewhat different CD4 cutoff may be required for the Bhutanese population. However, within the Bhutanese population, a single reference count may be advocated for adults disregarding the negligible numerical differences between age groups and gender.

Keywords :

Bhutan; CD4 count; healthy blood donors; Thimphu.

Full Article - PDF    Page 1-8 Article Metrics

DOI : 10.9734/IBRR/2018/41946

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