International Research Journal of Oncology, ..,Vol.: 1, Issue.: 1
Hypofractionated Radiotherapy for Localized Prostate Cancer: Clinical Outcome (Mansoura University)
Abeer Hussien Anter1* and Mohamed Farouk Akl1 1Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Egypt.
Abeer Hussien Anter1* and Mohamed Farouk Akl1
1Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Egypt.
(1) Krishnangshu Bhanja Choudhury, Assistant professor, Department of Radiotherapy, R. G. Kar Medical College and Hospital, Kolkata, India.
(1) Bahaa Ahmed Eldokany, Cairo University, Egypt.
(2) Kwasi Agyen-Mensah, University of Cape Coast, Ghana.
(3) Monica Mangoni, University of Florence, Italy.
Complete Peer review History: http://www.sciencedomain.org/review-history/24687
Purpose: In this study, we describe the efficacy and safety of hypo fractionated radiotherapy in treating patients with localized prostate cancer.
Patients and Methods: A total of 70 patients diagnosed with localized (T1-T2) prostatic adenocarcinoma. Low and intermediate risk groups were prospectively recruited between November 2012 and November 2016. Patients were treated with hypo-fractionated RT of 60 Gy in 20 fractions over 4 weeks. Androgen deprivation therapy was permitted for intermediate risk patients. The primary outcome was biochemical relapse free survival which defined as the nadir PSA post-radiotherapy plus 2 ng/ml according to PHOENIX criteria. Overall survival and treatment toxicity were secondary end points.
Results: With medium follow-up of 30 months; the three year biochemical relapse-free survival was 93.6%. Acute GU toxicity was detected as follows: 13(18.6%) patients experienced G1 toxicities while 11(15.7%) patients developed G2 toxicities. Acute G1 toxicity was detected with, 11.4% of patients reporting G1 toxicity and 10% experiencing G 2 toxicity. During the follow-up, three patients died; two from systemic disease progression; one patient expired due to cardiac cause. The 5 years overall survival was 90%.
Conclusion: Our data show that a Hypo-RT using 3D-CRT produces an excellent biochemical control and a low incidence of late GI and GU toxicity. Also in absence of IGRT or IMRT, we should use rigid restrictions and adequate margins to get reasonable rate of late toxicity.
Prostate cancer; hypofractionation; radiotherapy; prospective study.
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