Quick Menu

Upcoming Journals

International Journal of Research and Reports in Dentistry

International Journal of Research and Reports in Dentistry, ..,Vol.: 1, Issue.: 1


Evaluation of Differential Oral Cell-specific Responses to the E-cigarette Component Nicotine


Ian Pearson1, James Luke Taylor1 and Karl Kingsley2*

1Department of Clinical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, USA.

2Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, USA.


Article Information


(1) Kanupriya Gupta, Assisstant Professor, Department of Oral and Maxillofacial Pathology, Mithila Minority Dental College and Hospital, India.


(1) Priyanka Agarwal, Maharashtra University of Health Sciences, India.

(2) Lazos, Jerónimo Pablo, Universidad Nacional de Córdoba, Argentina.

Complete Peer review History: http://www.sciencedomain.org/review-history/24625




Objectives: The recent introduction of electronic cigarettes (EC) or e-cigarettes, also known as the electronic nicotine delivery device (ENDD), has been promoted as a safer alternative to tobacco products and smoking. Many groups have advocated for the use of ECs or ENDDs as a tool to reduce carcinogenic potential, while simultaneously promoting strategies and protocols for smoking and nicotine cessation. Based upon this information, the main objective of this study was to determine the biological effects of the most basic aerosol component of all ECs and ENDDs (nicotine) on cells and tissues specifically derived from the oral cavity. The working hypothesis was that no discernable effects would be apparent at the concentrations typically associated with EC and ENDD use.

Experimental Methods: In brief, oral cell lines were obtained, which included normal, non-cancerous Human Gingival Fibroblasts (HGF-1) and two oral squamous cell carcinomas (SCC25, CAL27). Cells were exposed to nicotine at concentrations equivalent to those found in e-cigarette mixtures (5.77 x 10-5 M) for five day proliferation and viability assays.

Results: The results of this study strongly suggest that nicotine may have negative effects on both cellular viability and cellular proliferation among cancerous and non-cancerous cells. Moreover, these effects appear to become more pronounced over time, suggesting that short-term exposure to vaping solutions comprised of water with small amounts of nicotine may be sufficient to induce these effects – at least in this experimental or in vitro setting.

Conclusions: In summary, these data provide further evidence that nicotine administration may present significant risks to cell viability and growth over time. In addition, this study demonstrated that these effects were evident in both cancerous and non-cancerous cells – a finding that may suggest more research in this area is needed to determine the mechanisms that might be shared between these differing cell types, which may also suggest more caution may be needed when advertising or marketing ECs or ENDDs are low- or no-risk alternatives to cigarette smoking.


Keywords :

Nicotine; e-cigarette; oral response.


Full Article - PDF    Page 1-10    Article Metrics

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.