British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 5 (11-20 February)
Prescribing Guide for Baclofen in the Treatment of Alcoholism – for Use by Physicians
Pascal Gache1, Renaud de Beaurepaire2*, Philippe Jaury3, Bernard Joussaume4, Annie Rapp5 and Patrick de La Selle6 120 rue des Deux-Ponts, 1205 Genève, Switzerland.
2Groupe Hospitalier Paul-Guiraud, 54 avenue de La République, 94806 Villejuif, France.
3Département de Médecine Générale, Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, Paris, France.
43 place Estienne d'Orves,"¨83150 Bandol, France.
5243 boulevard Raspail, 75014 Paris, France.
66 rue Paul Brousse,34000 Montpellier, France.
Pascal Gache1, Renaud de Beaurepaire2*, Philippe Jaury3, Bernard Joussaume4, Annie Rapp5 and Patrick de La Selle6
120 rue des Deux-Ponts, 1205 Genève, Switzerland.
(1) Jia Xu, University of Texas-M.D. Anderson Cancer Center, USA.
(2) James Adams, University of Southern California, USA.
Complete Peer review History: http://www.sciencedomain.org/review-history/2459
The purpose of this guide is to help doctors prescribe baclofen in the treatment of alcohol problems as there is, to date, no standardized way to prescribe this molecule in the treatment of alcohol dependence. The Recommended Medical Practices in respect of baclofen prescription generally proposes, for neurological treatment, increasing dosage by 15mg every 3 days, while suggesting flexibility, that is to say, adapting dosages individually. The proposals below reflect the experience of the authors to this paper, experience which itself has been based on the original method described by Olivier Ameisen [1,2]. The authors have, between them, treated more than 1500 patients with this medication, and they have learned gradually and empirically how to use baclofen to help patients in the best possible way with alcohol problems. The experience of the authors is that there is no absolute consensus and that prescribers may have different approaches and practices in the conduct of treatment. At the present time, it is impossible to give a definitive answer to the question.
Thebibliography (see References) includes four papers describing clinical experiences in which the authors have compiled their results [3,4,5,6].Other reports from the literature have also been taken in to account [7,8,9]. These recommendations are intended to help the prescription ofbaclofen.
Off-label; high dose; side-effects; prescription schedule.
Full Article - PDF Page 1164-1174
DOI : 10.9734/BJMMR/2014/7069Review History Comments