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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 5 (11-20 February)

Opinion Article

Recognizing Paradigm Instability in Theories of Carcinogenesis


Stuart G. Baker1*

1Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA.

Article Information


(1) Jia Xu, University of Texas-M.D. Anderson Cancer Center, USA.


(1) Nosheen Masood, Fatima Jinnah Women University, Pakistan.

(2) Anonymous.

Complete Peer review History:


The dominant view that cancer arises from successive mutations in somatic cells is so unquestioned that accumulating challenges from experimental and observational results are rarely addressed in the scientific literature. Based on these challenges, we argue that the scientific understanding of carcinogenesis has entered a period of paradigm instability. New research directions are therefore needed.

Keywords :

Cancer; funding; paradigm instability; paradox; research; somatic mutation theory; tissue organization field theory.

Full Article - PDF    Page 1149-1163

DOI : 10.9734/BJMMR/2014/6855

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