Quick Menu

Upcoming Journals

International Neuropsychiatric Disease Journal

International Neuropsychiatric Disease Journal, ISSN: 2321-7235,Vol.: 11, Issue.: 2


A Cross-Sectional Study of the Impact of Antipsychotic Medications on the Hematological Profile of Patients with Schizophrenia in a Tertiary Health Facility in Uyo, South-South, Nigeria


Henry E. Jombo1 and Timothy A. Ekwere2*

1Department of Mental Health, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria.

2Department of Haematology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria.


Article Information


(1) Pasquale Striano, Pediatric Neurology and Muscular Diseases Unit, University of Genoa, G. Gaslini Institute, Genova, Italy.


(1) Alicia Garcia-Falgueras, Spanish University, Spain.

(2) Mary V. Seeman, University of Toronto, Canada.

Complete Peer review History:




Objective: Antipsychotic drugs have been implicated as a potential cause of haematological toxicity. However, the seemingly mild and asymptomatic presentation is perhaps responsible for it not being frequently investigated. The aim of this study, therefore, was to determine the effect of antipsychotic drugs on the hematological profile of patients with schizophrenia.

Methods: This was a descriptive cross-sectional study involving 100 participants i.e. 60 subjects and 40 controls. 2.5 mls of blood was obtained from each participant for determination of full blood counts. Clinical data of subjects including their demographic characteristics, classes of antipsychotics, and duration of antipsychotic usage were obtained from their respective case files. Data was analysed using Statistical Package for Social Sciences for Windows Version 17. Significant level was set at p<0.05.

Results: The mean of the hematological parameters including haemoglobin concentration, absolute neutrophil counts and platelet counts were significantly lower among the subjects than the controls p=0.001, 0.04 and 0.001 respectively. Similarly, there was statistically significant differences in the mean platelet count, MPV and PCT of subjects and controls with p<0.001, 0.001 and 0.04 respectively. However, there was no association between the mean age and gender of subjects and absolute neutrophil count p=0.24 and 0.46 respectively.

Conclusion: Significant reduction in haematological parameters of subjects compared to the controls may suggest some degree of haemato-toxicity most likely attributable to the antipsychotic drug. Furthermore the absolute neutrophil count though significantly lower in the subjects did not show age or sex differences. Therefore, there is need to regularly monitor haematological indices of psychiatric patients during treatment with antipsychotics.


Keywords :

Antipsychotics; psychiatry; neutropaenia; blood dyscrasias.


Full Article - PDF    Page 1-9    Article Metrics


DOI : 10.9734/INDJ/2018/40894

Review History    Comments

Search this site

Advanced Search

Announcement & News

Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and its editors

We are happy to inform that Nature (Impact Factor: 41.6) confirmed high standard of SDI journal and ...

ISI Thomson Reuters selected British Journal of Pharmaceutical Research for Emerging Sources Citation Index

We are delighted to inform that ISI Thomson Reuters selected British Journal of Pharmaceutical Resea...

SCOPUS selected Annual Research & Review in Biology (ARRB)

We are delighted to inform that famous indexing organization SCOPUS (from Elsevier) selected  A...

Index Copernicus Evaluation Result Released

We are delighted to inform that Index Copernicus (a leading indexing organization from Pol...

Journal Repository (JR): Permanent Digital Archiving of SDI journals

SDI is happy to announce that all our journals are now permanently archived in Journal Repository (J...

SDI journal got 35th ranking in Publons

We are delighted to announce (as of 04/01/2016) that British Journal of Medicine and Medical Re...

Growth of SDI and world publication market

As of 2014, total 25,064 journals are competing in World market of journal publication. In 2011, tot...

Science (IF: 31) report confirmed the high standard of SDI journal

As per a recent report (Link) of Science journal (present Impact factor 31), one of our journal (Bri...

SDI introduced Post-publication peer review by its comment section

SDI journals encourage Post-publication peer review by its comment section   Policy details a...

SDI promotes transparent Advanced OPEN peer review

We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (...


  • No Awards listed.

Browser Compatibility : Mozila firefox, Google Crome and IE 7 & above. Creative Commons License Terms & Condition   |   Privacy Policy   |   Join Us   |   Help   |   Contact Us
© Copyright 2010-2018, SCIENCEDOMAIN international. All rights reserved.