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British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 4, Issue.: 3 (21-31 January)

Original-research-article

Morning Salivary Cortisol Associates with Elevated Serum Leptin Levels in Jordanian Young Men with Olive Pollen Induced Allergic Rhinitis

 

Mahmoud Abu-Samak1, Ahmad Abu-Zaiton2, Ahmad Al-Jaberi3, Ahmad Sundookah4, Omar Atrooz5, Khalid M. Abu khadra6, Rula Kuzaie4 and Wamidh H. Talib1*

1Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman, 11931, Jordan.
2Department of Biological Sciences, Al-al Bayt University, Amman, Jordan.
3Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, 11931, Jordan
4Department of Food and Clinical Nutrition, Applied Science University, Amman, 11931, Jordan.
5Department of Biological Sciences, Mu'tah University, Al Karak, Jordan.

6Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan.

Article Information

Editor(s):

(1) Tarek Tawfik Amin, Community Medicine, Faculty of Medicine, Cairo University, Egypt.

(2) Mohamed Essa, Department of Food Science and Nutrition, Sultan Qaboos University, Oman.

(3) Sinan Ince, Department of Pharmacology and Toxicology, University of Afyon Kocatepe, Turkey.

Reviewers:

(1) Anonymous

(2) Carl-Johan Törnhage, Karlstads University, Sweden.

(3) Anonymous

(4) Anonymous

Complete Peer review History: http://www.sciencedomain.org/review-history/2330

Abstracts

Aims: Recent studies have shown independently inter-correlations between allergy, obesity, leptin hormone, and stress markers. However, these findings were unclear and contradictory. Thus the aim of the present study is to evaluate diurnal levels of salivary cortisol and DHEA in sample of Jordanian young men with history of olive pollen-induced allergic rhinitis in relation to serum levels of leptin.
Methodology: 130 university male students aged (21.98±1.78) years, were divided into two groups (59 allergic and 71 non allergic). Fasting blood samples were collected and tested for blood glucose, lipid profile, serum leptin, and salivary stress hormones (cortisol and DHEA).
Results: Allergic subjects showed significantly higher means of serum leptin (p<0.0001), LDL (p<0.0001), Total cholesterol (p=0.001), and BMI (p= 0.004). Also BMI and Body weight significantly correlated with serum leptin in all subjects of the study. Stronger correlation was observed in allergic subjects (r = 0.650; r = 0.589) compared with non allergic subjects (r = 0.349; r = 0.383) respectively. Simple linear regression analysis showed that morning salivary cortisol ( p=0.006) and midnight salivary DHEA ( p=0.015 ), were significantly correlated in allergic subjects with the serum leptin levels concentration.
Conclusion: These results revealed an association between the morning salivary cortisol and elevated serum leptin levels in Jordanian young men with olive pollen induced allergic rhinitis.

Keywords :

Allergy, stress, obesity, salivary cortisol, DHEA, leptin, lipid, Jordanian

Full Article - PDF    Page 797-806

DOI : 10.9734/BJMMR/2014/5418

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